Method and apparatus for measuring analytes in blood bags
First Claim
1. A method for determining a concentration of at least one analyte in a sample contained in a blood bag or in tubing in fluid communication with said blood bag, using an instrument comprising at least one calibration algorithm for said at least one analyte, said method comprising:
- a) irradiating said sample in said tubing, or said blood bag, using a radiation source of about 475 nm to about 2,700 nm;
b) measuring absorbance from said sample for said at least one analyte; and
c) calculating a concentration of said at least one analyte using said absorbance and said at least one calibration algorithm.
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Abstract
The present invention provides a method for determining a concentration of at least one analyte in a sample contained in a blood bag or in tubing in fluid communication with said blood bag, using an instrument comprising at least one calibration algorithm for the at least one analyte. The method comprises irradiating a sample in the tubing or the blood bag, using a near infrared and adjacent visible radiation source. Then measuring absorbance from the sample for the at least one analyte, and calculating a concentration of the at least one analyte using the absorbance and the at least one calibration algorithm.
9 Citations
8 Claims
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1. A method for determining a concentration of at least one analyte in a sample contained in a blood bag or in tubing in fluid communication with said blood bag, using an instrument comprising at least one calibration algorithm for said at least one analyte, said method comprising:
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a) irradiating said sample in said tubing, or said blood bag, using a radiation source of about 475 nm to about 2,700 nm;
b) measuring absorbance from said sample for said at least one analyte; and
c) calculating a concentration of said at least one analyte using said absorbance and said at least one calibration algorithm. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining a concentration of one or more of haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobinin in a sample contained in a blood bag or in tubing in fluid communication with said blood bag, using an instrument comprising one or more calibration algorithms for each of said haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobin, said method comprising:
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a) irradiating said sample in said tubing or said blood bag using a radiation source of about 475 nm to about 2,700 nm;
b) measuring absorbance from said sample for said one or more of haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobin; and
c) calculating a concentration for one or more of said haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobinusing said absorbance and said one or more calibration algorithms, by combining first derivatives of at least two portions of a spectrum generated from said absorbance to provide said concentration.
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Specification