Method and reagents for analyzing the nucleotide sequence of nucleic acids

  • US 20020182601A1
  • Filed: 04/17/2001
  • Published: 12/05/2002
  • Est. Priority Date: 07/09/1998
  • Status: Active Grant
First Claim
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1. A mixture or set of sub-mixtures comprising X-mer precursors, wherein the X-mer precursors have a minimum length of 3 nucleotides;

  • wherein the mixture has a minimum mixture coverage complexity of at least 56/N or wherein the set of sub-mixtures has a composite mixture coverage complexity of at least 56/N, wherein N represents the number of distinct X-mer precursors in the mixture;

    wherein each sub-mixture in said set has a reduced mixture coverage complexity as compared with the composite mixture coverage complexity;

    wherein each sub-mixture comprises a plurality of X-mer precursors;

    wherein said length is selected independently for each X-mer precursor; and

    wherein the mixture or set of sub-mixtures further comprises a set of tags wherein each tag is covalently linked to at least one X-mer precursor through a cleavable linker.

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