High-efficiency microarray printing device
First Claim
Patent Images
1. A microarray print head, said print head comprising:
- a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between said spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of said capillaries.
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Abstract
This invention provides improved components (e.g. array “pins”, print head, substrate platen, print head platen, and the like) for microarray printing devices as well as microarray printing devices incorporating such components. In one embodiment, this invention provides a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between the spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of the capillaries.
34 Citations
61 Claims
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1. A microarray print head, said print head comprising:
a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between said spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of said capillaries. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 36, 37)
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15. A platen for positioning a substrate holder or a print head in a microarray printing device, said platen comprising:
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a support surface attached to a single guide rail such that said support surface can move along said guide rail, and motion of said support is constrained in a direction normal to said guide rail; and
a flexible coupling to an actuator wherein said flexible coupling is rigid in a direction parallel to said guide rail, but is flexible in another direction.
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31. A microarray printing device, said microarray printing device comprising:
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a microarray print head comprising a plurality of glass or quartz spotting capillaries disposed in a support that maintains a fixed spacing between said spotting capillaries and that permits the spotting capillaries to move in a direction parallel to the long axis of said capillaries; and
and a microarray substrate holder attached to a platen comprising;
a support surface attached to a single guide rail such that said support surface can move along said guide rail, and motion of said support is constrained in a direction normal to said guide rail; and
a flexible coupling to an actuator wherein said flexible coupling is rigid in a direction parallel to said guide rail, but is flexible in another direction. - View Dependent Claims (14, 32, 33, 34, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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55. A protein or nucleic acid microarray, said microarray comprising at least 1000 different array elements on an array substrate, said array elements comprising a protein or nucleic acid wherein
said array elements are separated by an average center to center spacing of about 130 μ - m or less; and
said protein or said nucleic acid is not a chemically synthesized protein or nucleic acid. - View Dependent Claims (56, 57, 58, 59, 60, 61)
- m or less; and
Specification