Intelligent polymerized crystalline colloidal array carbohydrate sensors
First Claim
1. A carbohydrate sensor comprising a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of detecting said carbohydrate.
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Abstract
The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of responding to glucose. The molecular recognition component may be a boronic acid, such as a phenylboronic acid, glucose oxidase, a combination of phenylboronic acid and poly(ethylene)glycol or crown ether, or another component capable of detecting glucose in various fluids and solutions. The glucose sensors of the present invention may be useful in the development of noninvasive or minimally invasive in vivo glucose sensors for patients having diabetes mellitus.
51 Citations
37 Claims
- 1. A carbohydrate sensor comprising a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of detecting said carbohydrate.
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8. A method for detecting the concentration of a carbohydrate in a solution comprising:
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preparing a carbohydrate sensor comprising a crystalline colloidal array polymerized in a hydrogel, wherein the hydrogel undergoes a volume change in response to the carbohydrate, and wherein said crystalline colloidal array has a lattice spacing that changes when the volume of the hydrogel changes, thereby causing the diffracted wavelength of the crystalline colloidal array to change;
contacting said polymerized crystalline colloidal array with said solution;
measuring the diffracted wavelength of said crystalline colloidal array before and after exposure to said solution; and
comparing the change in diffracted wavelength measurements before and after exposure to determine the concentration of the carbohydrate in said solution. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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- 23. A contact lens comprising a carbohydrate sensor, which comprises a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of detecting said carbohydrate.
- 27. An optical insert comprising a carbohydrate sensor, which comprises a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of detecting said carbohydrate.
- 33. A subcutaneous implant comprising a carbohydrate sensor, which comprises a biocompatible polymerized crystalline colloidal array (PCCA) and a molecular recognition component cable of detecting said carbohydrate.
Specification