Hypercrosslinked polymeric material for purification of physiological liquids of organism, and a method of producing the material

• US 20030027879A1
• Filed: 01/11/2001
• Published: 02/06/2003
• Est. Priority Date: 08/28/1998
• Status: Abandoned Application

• Current Assignee: Ludmiia Pavlova, Maria Tsyurupa, Vadim Davankov
• Original Assignee: Ludmiia Pavlova, Maria Tsyurupa, Vadim Davankov
• Inventors: Pavlova, Ludmiia, Davankov, Vadim, Tsyurupa, Maria
• Application Number:
  US09/848,601
• Publication Number:
  US 20030027879A1
• Time in Patent Office: Days
• US Class Current: 521/82
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01J 20/26 Synthetic macromolecular compounds
• CPC Class Codes: B01J 20/261 obtained by reactions only involving carbon to carbon unsaturated bonds macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F
• CPC Class Codes: B01J 20/267 Cross-linked polymers
• CPC Class Codes: B01J 20/2808 being less than 2 nm, i.e. micropores or nanopores
• CPC Class Codes: B01J 20/28083 being in the range 2-50 nm, i.e. mesopores
• CPC Class Codes: B01J 20/28085 being more than 50 nm, i.e. macropores

Abstract

Hypercrosslinked polymeric adsorbents exhibiting improved porosity, namely, a combination of micropores, mesopores and macropores, with an enhanced portion of mesopores, are produced by radical suspension polymerization of divinylbenzene or copolymerization of styrene with more than 40 mol % of the aromatic divinyl compound in the monomer mixture, in the presence of diluents or mixtures thereof, which properties are close to those of θ-solvents, so that the divinyl compounds form bridges in sufficient numbers to produce a stable porous polymer network without additional subsequent bridging.

Claims

1. A porous polymeric adsorbing material with adsorption capacity with respect to solutes in a molecular weight range of 5,000 to 50,000 Dalton, with an enhanced portion of mesopores, in addition to micropores and macropores, and which is prepared by a method consisting of the step of polymerization of an aromatic divinyl compound or copolymerization of an aromatic monovinyl compound with more than 40 mol % of an aromatic divinyl compound, so that the aromatic divinyl compound with the quantity of more than 40 mol % forms cross-linking bridges in such numbers which make a porous polymer network stable without additional subsequent bridging, in the presence of porogens or mixtures of porogens with properties close to those of θ

-solvents.

2. A material as defined in claim 1, wherein said aromatic divinyl compound is p- or m-divinylbenzene or mixtures thereof, p- or m-diisopropenylbenzene or mixtures thereof.

3. A material as defined in claim 1, wherein said aromatic monovinyl compounds are compounds selected from the group consisting of styrene, methylstyrene, ethylvinylbenzene and vinylbenzylchloride.

4. A material as defined in claim 1, wherein said porogens are porogens selected from the group consisting of cyclohexane, cyclohexanone and other θ

-solvents for polystyrene.

5. A material as defined in claim 1, wherein said porogens are θ

-solvents composed of mixtures of a good solvent for polystyrene and a non-solvent for polystyrene.

6. A material as defined in claim 5, wherein said solvents for polystyrene are selected from a group consisting of toluene, benzene, xylene, diethylbenzene, ethylene dichioride, propylene dichloride, tetrachloroethyene, dioxane and methylene dichloride.

7. A material as defined in claim 5, wherein said non-solvents for polystyrene are selected from a group consisting of aliphatic hydrocarbons, aliphatic alcohols and aliphatic acids.

8. A material as defined in claim 1, wherein said porogens or mixtures of porogens with properties close to those of θ

-solvents are used in amounts of 50 to 300% with respect to the volume of the comonomers.

9. A method of producing a porous polymeric adsorbing material with adsorption capacity with respect to solutes in a molecular weight range of 5,000 to 50,000 Dalton, with an enhanced portion of mesopores, in addition to micropores and macropores consisting of the step of performing polymerization of an aromatic divinyl compound, or copolymerization of an aromatic monovinyl compound with more than 40 mol % of an aromatic divinyl compound;

so that the aromatic divinyl compound with the quantity of more than 40 mol % forms cross-linking bridges in such numbers which make a porous polymer network stable without additional subsequent bridging; and

performing said polymerization or copolymerization in the presence of porogens or mixtures of porogens with properties close to those of θ

-solvents.

10. A method as defined in claim 9, wherein said aromatic divinyl compound is p- or m-divinylbenzene or mixtures thereof, p- or m-diisopropenylbenzene or mixtures thereof.

11. A method as defined in claim 9, wherein said aromatic monovinyl compounds are compounds selected from the group consisting of styrene, methylstyrene, ethylvinylbenzene and vinylbenzylchloride.

12. A method as defined in claim 9, wherein said porogens are porogens selected from the group consisting of cyclohexane, cyclohexanone and other θ

-solvents for polystyrene.

13. A method as defined in claim 9, wherein said porogens are θ

-solvents composed of mixtures of a good solvent for polystyrene and a non-solvent for polystyrene.

14. A method as defined in claim 13, wherein said solvents for polystyrene are selected from a group consisting of toluene, benzene, xylene, diethylbenzene, ethylene dichloride, propylene dichloride, tetrachloroethylene, dioxane and methylene dichloride.

15. A method as defined in claim 13, wherein said non-solvents for polystyrene are selected from a group consisting of aliphatic hydrocarbons, aliphatic alcohols and aliphatic acids.

16. A method as defined in claim 9, wherein said porogens or mixtures or porogens with properties close to those of θ

-solvents are used in amounts of 50 to 300% with respect to the volume of the comonomers.