Anti-irritating rosacea treatment

• US 20030068343A1
• Filed: 10/05/2001
• Published: 04/10/2003
• Est. Priority Date: 10/05/2001
• Status: Active Grant

• Current Assignee: Color Access Incorporated
• Original Assignee: Color Access Incorporated
• Inventors: Muizzuddin, Neelam, Marenus, Kenneth D., Maes, Daniel H.
• Granted Patent: US 6,680,062 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/59 Mixtures
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/41 Amines
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/9717 Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/987 of species other than mammals or birds
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.

Claims

1. A topical cosmetic or pharmaceutical composition for skin treated with a retinoid for a condition of rosacea comprising a combination of

a phytosphingosine;

an antioxidant component;

an anti-bacterial component comprising at least hinokitiol and a salicylate; and

an anti-irritating component comprising at least a polysaccharide and gorgonian extract.

2. The composition of claim 1 further comprising

about 0.01 to 10.0 percent of the phytosphingosine,

about 0.1 to 0.5 percent of the antioxidant component comprising at least a green tea,

about 0.05 to 0.2 percent of the hinokitiol,

about 0.1 to 5.0 percent of the salicylate,

about 0.05 to 0.2 percent of the gorgonian extract, and

about 0.5 to 2.0 percent of the polysaccharide.

3. The composition of claim 2 in which the salicylate is selected from the group consisting of salicylic acid and salicylic acid ester.

4. The composition of claim 1 which comprises said salicylate is present in an amount of from about 0.2 to 1.0 percent by weight of the total composition.

7. A method of treating telangiectasis comprising topically applying the compositions of claim 1.

8. A method of treating rosacea comprising topically applying the compositions of claim 1.

5. A method of decreasing irritation on skin treated with a retinoid for a condition of rosacea which comprises topically applying a salicylate, a phytosphingosine, and an anti-irritating component comprising a mixture of a green tea, a hinokitiol, a gorgonian extract, and a polysaccharide.

6. A method of decreasing redness on skin topically treated with a retinoid for a condition of rosacea comprising topically applying a phytosphingosine, a salicylate, and a mixture of an antioxidant component comprising at least a green tea, an anti-bacterial component comprising at least a hinokitiol, an anti-irritating component comprising a mixture of a gorgonian extract and a polysaccharide.

9. A topical cosmetic or pharmaceutical composition for treating the telangiectasic symptom of rosacea on skin treated with a retinoid comprising a combination of

a) about 0.01 to 10.0 percent phytosphingosine,

b) an effective amount of a combination of an antioxidant component comprising at least about 0.1 to 0.5 percent green tea,

c) an anti-bacterial component comprising at least about 0.05 to 0.2 percent hinokitiol and about 0.1 to 5.0 percent salicylate, and

d) an anti-irritant component comprising a combination of about 0.05 to 0.2 percent gorgonian extract and about 0.5 to 2.0 percent polysaccharide.

10. A rosacea treatment system for topical application to skin treated with a retinoid comprising

a) an anti-bacterial component comprising about 0.1 to 5.0 percent of a salicylic acid and about 0.05 to 0.2 percent hinokitiol,

b) about 0.01 to 10.0 percent phytosphingosine,

c) an effective amount of an antioxidant component comprising at least about 0.1 to 0.5 percent green tea, and

d) an anti-irritating component comprising a combination of about 0.05 to 0.2 percent gorgonian extract, and about 0.5 to 2.0 percent polysaccharide.