Thrombolysis and chronic anticoagulation therapy
First Claim
1. A method for providing thrombolytic and anticoagulation therapy, comprising:
- providing a stimulator that generates a pulse in accordance with prescribed parameters;
providing a catheter connected to the stimulator, which catheter includes a discharge portion;
implanting the catheter discharge portion adjacent to at least one tissue to be stimulated;
implanting the stimulator at a location remote from the at least one tissue to be stimulated;
tunneling the catheter subcutaneously to the stimulator location; and
delivering via the stimulator and catheter infusion pulses of at least one drug as thrombolytic and anticoagulation treatment to at least one tissue, which tissue comprises at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation.
2 Assignments
0 Petitions
Accused Products
Abstract
Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.
214 Citations
22 Claims
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1. A method for providing thrombolytic and anticoagulation therapy, comprising:
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providing a stimulator that generates a pulse in accordance with prescribed parameters;
providing a catheter connected to the stimulator, which catheter includes a discharge portion;
implanting the catheter discharge portion adjacent to at least one tissue to be stimulated;
implanting the stimulator at a location remote from the at least one tissue to be stimulated;
tunneling the catheter subcutaneously to the stimulator location; and
delivering via the stimulator and catheter infusion pulses of at least one drug as thrombolytic and anticoagulation treatment to at least one tissue, which tissue comprises at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for providing thrombolytic and anticoagulation therapy, comprising:
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providing a stimulator that generates a pulse in accordance with prescribed parameters;
providing a catheter connected to the stimulator, which catheter includes a discharge portion;
implanting the catheter discharge portion adjacent to at least one tissue to be stimulated;
implanting the stimulator at a location remote from the at least one tissue to be stimulated;
tunneling the catheter subcutaneously to the stimulator location;
delivering via the stimulator and catheter infusion pulses of at least one drug as thrombolytic and anticoagulation treatment to at least one tissue, which tissue comprises at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation; and
causing modulation of arteriole lumen area to modulate perfusion and treatment delivery via the arterioles. - View Dependent Claims (19)
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20. A system for providing thrombolytic and anticoagulation therapy, comprising:
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means for generating infusion pulses of at least one drug in accordance with prescribed parameters, which at least one drug provides thrombolytic and anticoagulation treatment;
means for providing the prescribed parameters;
means for delivering the infusion pulses to at least one tissue, which tissue comprises at least one of a coronary artery, a coronary vein, the coronary sinus, the left ventricle, the left atrium, the surface of the myocardium, a pulmonary vein, a carotid artery, the anterior cerebral artery, the middle cerebral artery, the posterior cerebral artery, the circle of Willis, a meningeal artery, the basilar artery, a pulmonary artery, the superior vena cava, the inferior vena cava, the right ventricle, the right atrium, the aorta, a common iliac vessel, an internal iliac vessel, an external iliac vessel, a femoral vessel, a renal vessel, the celiac trunk, the middle colic artery, a superior mesenteric vessel, an inferior mesenteric vessel, a deep vein of the leg, a vessel that influences coronary circulation, a vessel that influences cerebral circulation, a vessel that influences pulmonary circulation, a vessel that influences circulation of the lower limbs, and a vessel that influences visceral circulation. - View Dependent Claims (21, 22)
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Specification