Translucent nanoemulsion, production method, and uses thereof in the cosmetic, dermatological and/or opthalmological fields

• US 20030087967A1
• Filed: 07/30/2002
• Published: 05/08/2003
• Est. Priority Date: 01/18/2001
• Status: Active Grant

• Current Assignee: L'Oreal SA
• Original Assignee: L'Oreal SA
• Inventors: Quemin, Eric
• Granted Patent: US 6,902,737 B2
• Time in Patent Office: Days
• US Class Current: 514/772
• CPC Class Codes: A61K 2800/21 Emulsions characterized by droplet sizes below 1 micron
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/4973 with oxygen as the only hetero atom
• CPC Class Codes: A61K 8/55 Phosphorus compounds
• CPC Class Codes: A61K 8/553 Phospholipids, e.g. lecithin
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61Q 1/00 Make-up preparations; Body powders; Preparations for removing make-up
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 Preparations for dry skin
• CPC Class Codes: A61Q 5/00 Preparations for care of the hair
• CPC Class Codes: A61Q 5/04 Preparations for permanent waving or straightening the hair
• CPC Class Codes: A61Q 5/06 Preparations for styling the hair, e.g. by temporary shaping or colouring
• CPC Class Codes: A61Q 5/10 Preparations for permanently dyeing the hair
• CPC Class Codes: A61Q 5/12 Preparations containing hair conditioners
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C09K 23/017 : Mixtures of compounds
• CPC Class Codes: C09K 23/018 : Mixtures of two or more different organic oxygen-containing compounds

Abstract

The nanoemulsion according to the invention comprises an oily phase dispersed in an aqueous phase, having oil globules with a number-average size less than 100 nm, characterized in that it contains a ternary surfactant system comprising:

a) a mixture of at least two nonionic surfactants comprising at least one ethoxylated fatty ester comprising 8 to 100 ethylene oxide units and at least one fatty acid ester of sorbitan; and

b) at least one ionic surfactant chosen from alkali metal salts of cetyl phosphate and alkali metal salts of palmitoyl sarcosinate.

Use in the manufacture of cosmetic, dermatological and ophthalmological compositions.

Claims

1. Nanoemulsion comprising an oily phase dispersed in an aqueous phase, having oil globules with a number-average size less than 100 nm, characterized in that it contains a ternary surfactant system comprising:

a) a mixture of at least two nonionic surfactants comprising at least one ethoxylated fatty ester comprising 8 to 100 ethylene oxide units and at least one fatty acid ester of sorbitan; and

b) at least one ionic surfactant chosen from alkali metal salts of cetyl phosphate and alkali metal salts of palmitoyl sarcosinate.

2. Nanoemulsion according to claim 1, characterized in that the ethoxylated fatty ester comprises from 10 to 80 ethylene oxide units.

3. Nanoemulsion according to claim 1, characterized in that the ethoxylated fatty ester comprises 40 ethylene oxide units.

4. Nanoemulsion according to any one of the preceding claims, characterized in that the ethoxylated fatty ester is polyethylene glycol stearate 40 EO and the fatty acid ester of sorbitan is sorbitan tristearate.

5. Nanoemulsion according to any one of the preceding claims, characterized in that the ionic surfactant is chosen from potassium cetyl phosphate and sodium palmitoyl sarcosinate, and mixtures thereof.

6. Nanoemulsion according to any one of the preceding claims, characterized in that the weight ratio of the ionic surfactant (b) to the mixture of nonionic surfactants (a) is such that:

0.02≦

b/a≦

75 and preferably 0.02≦

b/a≦

10.

7. Nanoemulsion according to any one of the preceding claims, characterized in that the weight ratio of the ethoxylated fatty ester to the fatty acid ester of sorbitan ranges from 0.02 to 100 and preferably from 0.04 to 80.

8. Nanoemulsion according to any one of the preceding claims, characterized in that the fatty acid ester of sorbitan represents 0.1% to 10% by weight and preferably 0.5% to 5% by weight relative to the total weight of the nanoemulsion.

9. Nanoemulsion according to any one of the preceding claims, characterized in that the ethoxylated fatty ester represents from 0.01% to 10% by weight and preferably 0.1% to 5% by weight relative to the total weight of the nanoemulsion.

10. Nanoemulsion according to any one of the preceding claims, characterized in that the content of ionic surfactant represents from 0.05% to 10% and preferably 0.2% to 5% by weight relative to the total weight of the nanoemulsion.

11. Nanoemulsion according to any one of the preceding claims, characterized in that the oily phase represents from 0.5% to 40% by weight and preferably from 5% to 30% by weight relative to the total weight of the nanoemulsion.

12. Nanoemulsion according to any one of the preceding claims, characterized in that the oily phase comprises an oil chosen from oils of animal or plant origin, mineral oils, synthetic oils, silicone oils and aliphatic hydrocarbons, and mixtures thereof.

13. Nanoemulsion according to any one of the preceding claims, characterized in that the oil is a hydrogenated polyisobutene, in particular parleam oil.

14. Nanoemulsion according to claim 13, characterized in that it also comprises at least one other fatty substance chosen from fatty alcohols, fatty acids, waxes and gums, and mixtures thereof.

15. Nanoemulsion according to claim 14, characterized in that the other fatty substance represents from 0% to 10% by weight and preferably 2% to 5% by weight relative to the total weight of the nanoemulsion.

16. Nanoemulsion according to claim 13 or 14, characterized in that the fatty alcohols are chosen from stearyl alcohol, cetyl alcohol and behenyl alcohol, and the fatty acids are chosen from stearic acid, palmitic acid and behenic acid.

17. Nanoemulsion according to claim 16, characterized in that the fatty alcohol is cetyl alcohol.

18. Nanoemulsion according to claim 14 or 15, characterized in that the other fatty substance is glyceryl mono-, di- or tripalmitostearate.

19. Nanoemulsion according to any one of the preceding claims, characterized in that it contains a cosmetic, dermatological or ophthalmological active agent.

20. Composition for topical use, characterized in that it contains a nanoemulsion according to any one of claims 1 to 19.

21. Cosmetic use of the nanoemulsion according to any one of claims 1 to 18, to care for, treat and/or make up the skin, the face and/or the scalp.

22. Cosmetic use of the nanoemulsion according to any one of claims 1 to 18, to care for and/or treat the hair.

23. Use of the nanoemulsion according to any one of claims 1 to 18, for the manufacture of a dermatological or ophthalmological composition.

24. Cosmetic process for caring for and/or moisturizing the skin, the mucous membranes and/or the scalp, characterized in that a nanoemulsion according to any one of claims 1 to 18 is applied to the skin, the mucous membranes and/or the scalp.

25. Process for preparing a nanoemulsion according to any one of claims 1 to 19, which comprises in mixing together the aqueous phase and the oily phase, with vigorous stirring, at a temperature ranging from 60 to 95°

C., and then in homogenizing at a pressure ranging from 6×

10⁷ Pa to 18×

10⁷ Pa.

26. Process according to claim 25, characterized in that the shear ranges from 2×

10⁶ s<sup>−

1</sup> to 5×

10⁶ s<sup>−

1</sup>.