Feedback mechanism for deep brain stimulation
First Claim
1. A method for improving cognitive function of a conscious patient, said method comprising:
- selecting a conscious patient;
applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to improve the patient'"'"'s cognitive function;
detecting internally generated movement of the patient; and
controlling said applying electrical stimulation in response to detected internally generated movement of the patient.
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Abstract
Disclosed is a method for improving cognitive function or for improving coordination of function across a patient'"'"'s cortical regions. The method includes applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals. Internally generated movement of the patient is then detected and, in response to such internally generated movement, application of electrical stimulation is controlled. The method of the present invention has a number of benefits, including increasing flexibility in identifying targets for stimulation, improving the probability of successfully treating brain injury, and permitting patient biofeedback and self-regulation.
153 Citations
44 Claims
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1. A method for improving cognitive function of a conscious patient, said method comprising:
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selecting a conscious patient;
applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to improve the patient'"'"'s cognitive function;
detecting internally generated movement of the patient; and
controlling said applying electrical stimulation in response to detected internally generated movement of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 29, 30, 31, 33, 34, 35, 36, 37, 38, 39, 40)
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- 24. A method according to claim 24, wherein electrical stimulation is applied periodically.
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32. A method according to claim 32, wherein the internally generated movement of the patient is saccadic movement.
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41. A method for improving coordination of function across cortical regions in a patient comprising:
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applying electrical stimulation to two or more subdivisions of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals, wherein the two or more subdivisions of the patient'"'"'s subcortical structures modulate separate cortical regions;
detecting internally generated movement of the patient; and
controlling said applying electrical stimulation in response to detected internally generated movement of the patient. - View Dependent Claims (42, 43, 44)
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Specification