Systems, methods, and compositions for achieving closure of vascular puncture sites
First Claim
1. An assembly for dispensing fluid comprising a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber;
- and an applicator comprising a first region for receiving the dispenser and a second region for receiving a container containing a second material, a first passage coupling the dispenser, when received by the first region, with the container, when received by the second region, so that the first material can be conveyed into the container in response to operation of the actuator, thereby forming a mixture of the first and second materials in the container, and a second passage that conveys the mixture from the container in response to operation of the actuator.
2 Assignments
0 Petitions
Accused Products
Abstract
Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.
200 Citations
27 Claims
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1. An assembly for dispensing fluid comprising
a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber; - and
an applicator comprising a first region for receiving the dispenser and a second region for receiving a container containing a second material, a first passage coupling the dispenser, when received by the first region, with the container, when received by the second region, so that the first material can be conveyed into the container in response to operation of the actuator, thereby forming a mixture of the first and second materials in the container, and a second passage that conveys the mixture from the container in response to operation of the actuator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A formative component assembly to house a closure material, which, in use, is dispensed to seal a puncture site in a blood vessel, the closure material comprising a mixture of first and second materials which, upon mixing, undergo a reaction to form a solid closure material composition, the formative component assembly comprising
a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber; - and
an applicator comprising a first region for receiving the dispenser and a second region for receiving a container containing a second material, a first passage coupling the dispenser, when received by the first region, with the container, when received by the second region, so that the first material can be conveyed into the container in response to operation of the actuator, thereby forming a mixture of the first and second materials in the container, and a second passage that conveys the mixture from the container in response to operation of the actuator. - View Dependent Claims (10, 11)
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12. A method for dispensing fluid comprising the steps of
coupling a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber with a container containing a second material; -
operating the actuator to convey the first material into the container, thereby forming a mixture of the first and second materials in the container; and
operating the actuator to convey the mixture from the container.
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13. A method of dispensing a closure material to seal a puncture site in a blood vessel, the closure material comprising a mixture of first and second materials which, upon mixing, undergo a reaction to form a solid closure material composition, comprising the steps of
coupling a dispenser having a chamber for containing the first material and an actuator for dispensing the first material from the chamber with a container containing the second material; -
operating the actuator to convey the first material into the container, thereby forming the mixture of the first and second materials in the container; and
operating the actuator to convey the mixture from the container.
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14. An assembly comprising
a biocompatible polymer comprising poly(ethylene glycol) (PEG) with a functionality of at least three in lyophilized form, and a container holding the polymer in lyophilized form.
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21. A method of dispensing a polymer that is moisture sensitive comprising the steps of
(1) dissolving the polymer in an aqueous solution to form a dissolved polymer solution, (2) lyophilizing the dissolved polymer solution to form a lyophilized polymer, (3) reconstituting the lyophilized polymer mixture with an aqueous solution to form a reconstituted polymer solution, (4) dispensing the reconstituted polymer solution.
Specification