Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals

• US 20030129261A1
• Filed: 07/11/2002
• Published: 07/10/2003
• Est. Priority Date: 02/13/1998
• Status: Active Grant

• Current Assignee: Nutramax Laboratories Incorporated
• Original Assignee: Nutramax Laboratories Incorporated
• Inventors: Henderson, Todd R., Hammad, Tarek, Henderson, Robert W., Lippiello, Louis, Soliman, Medhat, Corson, Barbara E.
• Granted Patent: US 6,797,289 B2
• Time in Patent Office: Days
• US Class Current: 424/757
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61K 38/446 Superoxide dismutase (1.15)
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Claims

1. A composition for the treatment, repair or prevention of damage to connective tissue comprising one or more avocado/soybean unsaponifiables and one or more compounds selected from the group consisting of an aminosugars, GAGs, SAMe, SOD, L-ergothionine, collagen type II, diacerin, arachadonic acid, and tetracycline-like compounds.

4. A method of preventing, treating or repairing damage to connective tissue in humans and animals comprising administering any of the compositions of claim 1 to a human or animal in need thereof.

2. A composition for the treatment, repair or prevention of damage to connective tissue comprising an analgesic from the group consisting of a non-steroid, non-NSAID analgesic and one or more compounds selected from the group consisting of aminosugars, GAGs, SAMe, SOD, L-ergothionine, collagen type II, diacerin, arachadonic acid, tetracycline-like compounds, and one or more ASUs.

3. The composition of claim 2 in which the analgesic is selected from the group consisting of acetaminophen and tramadol.

5. A method of preventing, treating or repairing damage to connective tissue in humans and animals comprising administering any of the compositions of claim 2 to a human or animal in need thereof.