Methods to mobilize progenitor/stem cells

  • US 20030130250A1
  • Filed: 07/30/2002
  • Published: 07/10/2003
  • Est. Priority Date: 07/31/2001
  • Status: Active Grant
First Claim
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1. A method to enhance the population of progenitor and/or stem cells, in a subject, which method comprises administering to said subject a compound of the formula Z-linker-Z′





  • (1) or pharmaceutically acceptable salt or prodrug form thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 2-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system;

    or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′

    may be embodied in a form as defined by Z above, or alternatively may be of the formula —

    N(R)—

    (CR2)n

    X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and x is an aromatic ring, including heteroaromatic rings, or is a mercaptan;



    linker”

    represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms;

    in an amount effective to elevate said progenitor and/or stem cell population in said subject;

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