Tablet composition

• US 20030147951A1
• Filed: 02/05/2003
• Published: 08/07/2003
• Est. Priority Date: 11/15/1996
• Status: Active Grant

• Current Assignee: EA Pharma Co., Ltd (Ajinomoto Co., Inc.)
• Original Assignee: Ajinomoto Co., Inc.
• Inventors: Ninomiya, Nobutaka, Kaida, Masato, Ozaki, Masanao, Ando, Takahiko, Yabuki, Akira
• Granted Patent: US 6,844,008 B2
• Time in Patent Office: Days
• US Class Current: 424/465
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61K 9/2853 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/2866 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

A tablet composition containing N-(trans-4-isopropylcyclobexanecarbonyl)-D-phenylalanine and low sustituted hydxoxypropylcellulose is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to inhibit the rise of the blood sugar levels of diabetics after meals.

Claims

1. A tablet composition containing N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine and low sustituted hydroxypropylcellulose.

2. The tablet composition according to claim 1, wherein an amount of the low sustituted hydchoxypropylcellulose contained therein is 5 to 50% by weight.

3. The tablet composition according to claim 1, which further contains a filler.

4. The tablet composition according to claim 3, wherein at least one kind of the filler is lactose.

5. The tablet composition according to claim 1, which further contains hydroxypropyl cellulose.

6. The tablet composition according to claim 5, wherein the hydroxypropyl cellulose contains 53.4 to 77.5% by weight of hydioxypropoxyl group.

7. A tablet composition containing 5 to 50% by weight of N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine, 5 to 40% by weight of low sustituted hydroxypropylcellulose and 10 to 90% by weight of a filler.

8. The tablet composition according to claim 7, wherein the filler is lactose.

9. The tablet composition according to claim 7, which further contains hydroxypropyl cellulose.

10. The tablet composition according to claim 9, wherein the hydroxypropyl cellulose contains 53.4 to 77.5% by weight of hydroxypropoxyl group.

11. A tablet composition containing 5 to 50% by weight of N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine, 5 to 40% by weight of low sustituted hydroxypropylcellulose having a hydroxypropyl group content of 5.0 to 16.0% by weight, 10 to 90% by weight of a filler and 0.1 to 5% by weight of hydioxypropyl cellulose having a hydroxypropyl group content of 53.4 to 77.5% by weight.

12. The tablet composition according to claim 11, wherein the filler is lactose.