Hydrogel compositions
First Claim
1. A hydrogel composition comprised of a discontinuous hydrophobic phase and a hydrophilic phase, wherein:
- (a) the discontinuous hydrophobic phase comprises (i) a hydrophobic polymer, (ii) a plasticizer, (iii) a tackifying resin, and (iv) an optional antioxidant; and
(b) the hydrophilic phase is either discontinuous or continuous.
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Accused Products
Abstract
Hydrogel compositions are provided (a) that have a continuous hydrophobic phase and a discontinuous hydrophilic phase, (b) that have a discontinuous hydrophilic phase and a continuous hydrophilic phase, or (c) that are entirely composed of a continuous hydrophilic phase. The hydrophobic phase, if present, is composed of a hydrophobic polymer, particularly a hydrophobic pressure-sensitive adhesive (PSA), a plasticizing elastomer, a tackifying resin, and an optional antioxidant. The discontinuous hydrophilic phase, if present, is composed of a crosslinked hydrophilic polymer, particularly a crosslinked cellulosic polymer such as crosslinked sodium carboxymethylcellulose. For those hydrogel compositions containing a continuous hydrophilic phase, the components of the phase include a cellulose ester composition or an acrylate polymer or copolymer, and a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto. Films prepared from hydrogel compositions containing or entirely composed of the aforementioned continuous hydrophilic phase can be made translucent, and may be prepared using either melt extrusion or solution casting. A preferred use of the hydrogel compositions is in wound dressings, although numerous other uses are possible as well.
330 Citations
83 Claims
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1. A hydrogel composition comprised of a discontinuous hydrophobic phase and a hydrophilic phase, wherein:
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(a) the discontinuous hydrophobic phase comprises (i) a hydrophobic polymer, (ii) a plasticizer, (iii) a tackifying resin, and (iv) an optional antioxidant; and
(b) the hydrophilic phase is either discontinuous or continuous. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 74, 75, 76)
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49. A translucent hydrogel composition comprising:
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(a) a water-swellable polymer that is insoluble in water at a pH of less than 8.5; and
(b) a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, wherein the relative quantities of the water-swellable polymer, the hydrophilic polymer, and the complementary oligomer are selected so as to render the hydrogel composition translucent. - View Dependent Claims (50, 73)
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51. A translucent hydrogel composition comprising:
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(a) approximately 30 wt. % to approximately 40 wt. % of a cellulose ester composition selected from the group consisting of cellulose acetate butyrate, cellulose acetate propionate, and mixtures thereof;
(b) approximately 25 wt. % to approximately 30 wt. % of a hydrophilic polymer composed of a poly(N-vinyl lactam); and
(c) approximately 30 wt. % to approximately 35 wt. % of a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, wherein the complementary oligomer is polyethylene glycol having a molecular weight in the range of 300 to 600. - View Dependent Claims (52, 53, 54, 55)
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56. A hydrogel composition comprising:
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(a) a water-swellable polymer insoluble in water at a pH of less than 8.5, said polymer selected from polymers and copolymers of acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, and/or ethyl methacrylate; and
(b) a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding thereto. - View Dependent Claims (57, 58, 59, 60, 61)
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72. A wound dressing having a translucent inner region for viewing a covered wound, comprising a substrate having:
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a body facing surface;
an outwardly facing surface;
a peripheral skin contact adhesive on the body facing-surface providing means for affixing the wound dressing to a body surface in the region of a wound;
a translucent inner region; and
,contained within the translucent inner region and on the body-facing surface of the wound dressing, a translucent hydrogel composition for absorbing wound exudate located within a central wound-contacting portion of the wound dressing.
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77. A method of forming a hydrogel film having a discontinuous hydrophobic phase comprising a hydrophobic polymer, a plasticizing elastomer, a tackifying resin, and an optional antioxidant, and a hydrophilic phase that is either discontinuous or continuous, wherein the method comprises:
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melt processing the components of the hydrophobic and hydrophilic phases through an extruder to form an extruded hydrogel composition;
placing the extruded hydrogel composition on a substrate; and
applying pressure to the hydrogel layer to form a hydrogel film on the substrate. - View Dependent Claims (78, 79)
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80. A method of forming a translucent hydrogel film comprised of a continuous hydrophilic phase, wherein the method comprises:
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melt processing through an extruder a mixture of a cellulose ester composition, a hydrophilic polymer, and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, to form an extruded hydrogel composition;
placing the extruded hydrogel composition on a substrate; and
applying pressure to the hydrogel layer to form a hydrogel film on the substrate, wherein the relative quantities of the cellulose ester composition, the hydrophilic polymer, and the complementary oligomer are selected so as to render the hydrogel composition translucent. - View Dependent Claims (81, 82)
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83. A method for preparing a translucent hydrogel film suitable for incorporation into a wound dressing, the method comprising:
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preparing a solution of a cellulose ester composition, a hydrophilic polymer, and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, in a solvent;
depositing a layer of the solution on a substrate to provide a coating thereon; and
heating the coated substrate to a temperature in the range of about 80°
C. to about 100°
C. for a time period in the range of about 1 to 4 hours, thereby providing a hydrogel film on the substrate,wherein the relative quantities of the cellulose ester composition, the hydrophilic polymer, and the complementary oligomer are selected so that the hydrogel film is translucent.
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Specification