Effervescent compositions comprising bisphosphonates and methods related thereto
First Claim
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1. An effervescent composition comprising:
- (a) a bisphosphonate, (b) an acid component, and (c) an alkaline effervescing component, wherein the composition when dissolved in water produces a solution having a buffered pH of about 3 to about 6.5.
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Abstract
The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
42 Citations
42 Claims
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1. An effervescent composition comprising:
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(a) a bisphosphonate, (b) an acid component, and (c) an alkaline effervescing component, wherein the composition when dissolved in water produces a solution having a buffered pH of about 3 to about 6.5. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 27, 28, 29, 30, 31, 32, 33, 34)
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21. An effervescent composition comprising:
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(a) a bisphosphonate, (b) an anti-ulcer agent, (c) an acid component, (d) an alkaline effervescing component, and, optionally, one or more of the following ingredients selected from;
(e) a sweetener, (f) a flavorant, and (g) a solubilizing agent. - View Dependent Claims (22, 23, 24, 35, 36, 37, 38)
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25. An effervescent composition comprising:
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(a) a microencapsulated bisphosphonate, (b) an acid component, (c) an alkaline effervescing component, and optionally (d) an anti-ulcer agent. - View Dependent Claims (26, 39, 40, 41, 42)
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Specification