Apparatus and method for spectroscopic analysis of tissue to detect diabetes in an individual
First Claim
1. A method for indicating diabetes in an individual utilizing tissue optical information from the individual comprising the steps of:
- obtaining tissue optical information from the individual, the tissue optical information including information from at least one wavelength indicative of glycosylation end product content in the tissue;
providing a multivariate algorithm developed from a database of optical information from individuals having a known disease state, the multivariate algorithm having at least one factor dependent on information from the at least one wavelength indicative of glycosylation end products in the tissue; and
applying the multivariate algorithm to the tissue optical information from the individual to indicate diabetes.
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Abstract
Apparatus and methods for spectroscopic analysis of human tissue to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of diabetes in an individual. Tissue optical information of an individual, including at least a measurement of at least one wavelength or group of wavelengths indicative of glycosylated collagen content in tissue, is analyzed using multivariate techniques. The multivariate techniques include an algorithm developed from optical information from individuals having a known disease state. At least one factor in the algorithm is dependent on or a function of the measurement of the at least one wavelength or group of wavelengths indicative of glycosylated collagen content in tissue from the optical information of individuals forming the database.
25 Citations
25 Claims
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1. A method for indicating diabetes in an individual utilizing tissue optical information from the individual comprising the steps of:
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obtaining tissue optical information from the individual, the tissue optical information including information from at least one wavelength indicative of glycosylation end product content in the tissue;
providing a multivariate algorithm developed from a database of optical information from individuals having a known disease state, the multivariate algorithm having at least one factor dependent on information from the at least one wavelength indicative of glycosylation end products in the tissue; and
applying the multivariate algorithm to the tissue optical information from the individual to indicate diabetes. - View Dependent Claims (2, 3, 4, 5, 23, 24, 25)
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6. A method for classifying an individual as non-diabetic, diabetic or indicating a probability of becoming diabetic utilizing a database of tissue optical information from other individuals having known disease states, the optical information including information from at least one wavelength indicative of glycosylation end product content in the tissue, the method comprising the steps of:
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obtaining tissue optical information from the individual, the tissue optical information including information from the at least one wavelength indicative of glycosylation end product content in the tissue; and
using a multivariate algorithm to classify the individual as diabetic, non-diabetic or indicating a probability of becoming diabetic, the multivariate algorithm including at least one factor dependent on the information from the at least one wavelength indicative of glycosylation end product content in the tissue. - View Dependent Claims (7, 8, 9, 10)
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11. A method for non-invasively indicating diabetes using spectroscopic measurements of human tissue comprising the steps of:
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providing an illumination source and irradiating tissue with light having at least one wavelength indicative of glycosylation end product content in the irradiated tissue;
collecting at least a portion of the light exiting the irradiated tissue;
measuring at least a portion of the spectrum of the light collected from the tissue; and
applying multivariate techniques to the measured spectra to predict the probability of a subject having diabetes, the multivariate techniques including as a factor the at least one wavelength indicative of glycosylation end product content in the irradiated tissue. - View Dependent Claims (12, 13, 14)
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15. An apparatus for determining the probability, progression or level of diabetes, the apparatus comprising:
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a light source that generates light, including light at at least one wavelength indicative of glycosylated end products in tissue;
a sampling means for coupling the light to tissue and collecting the light modified by the tissue;
a spectrometer coupled to the sampling means for measuring the optical information of the modified light collected from the tissue; and
means for processing the optical information to determine the probability, progression or level of diabetes, the means including an algorithm having as a factor the optical information from the at least one wavelength indicative of glycosylated end products in tissue. - View Dependent Claims (16, 17, 18)
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19. An apparatus for non-invasively detecting the probability, progression or level of diabetes in human tissue by near-infrared spectroscopy comprising:
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an illumination subsystem which generates near infrared light including at least one wavelength indicative of glycosylated collagen content in human tissue;
a tissue sampling subsystem optically coupled to the illumination subsystem which receives at least a portion of the infrared light, the tissue sampling subsystem including means for irradiating human tissue with at least a portion of the received infrared light and collecting at least a portion of the light diffusely reflected from the human tissue;
an FTIR spectrometer subsystem optically coupled to the tissue sampling subsystem to receive at least a portion of the light diffusely reflected from the tissue, the FTIR spectrometer subsystem including a spectrometer that creates an interferogram, the FTIR spectrometer subsystem further including a detector which receives the interferogram and converts the interferogram to an electrical representation;
a data acquisition subsystem which receives the electrical representation of the interferogram, the data acquisition subsystem including means for amplifying and filtering the electrical representation and converting a resulting electrical signal to its digital representation; and
a computing subsystem for receiving the digital representation and further including a multivariate algorithm for detecting the probability, progression or level of diabetes, wherein the algorithm includes at least one factor dependent on the measurement of the at least one wavelength indicative of glycosylated collagen content in human tissue. - View Dependent Claims (20, 21, 22)
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Specification