Multi component controlled release system for anhydrous cosmetic compositons

• US 20030198652A1
• Filed: 04/17/2002
• Published: 10/23/2003
• Est. Priority Date: 04/17/2002
• Status: Active Grant

• Current Assignee: Salvona LLC
• Original Assignee: Salvona IP LLC
• Inventors: David Shefer, Shmuel, Shefer, Adi
• Granted Patent: US 7,115,282 B2
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0287 the particulate containing a solid-in-solid dispersion
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/001 Preparations for care of the lips
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to an improved controlled release system that can be incorporated into anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or different from those encapsulated in the micro-sphere. The encapsulation of one or more fragrances, flavors or active agents in the various components of the system, such as nano-spheres and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor character) during the use of the product, in response to moisture, such as wetting the lips, perspiration, and the like. The incorporation of the controlled release system of the present invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in the solid hydrophobic nano-spheres over an extended period of time.

Claims

1. An anhydrous composition comprising:

a plurality of solid nano-spheres, each of said solid nano-spheres comprising an effective amount of a first active agent said plurality of nano-spheres being encapsulated in a moisture sensitive micro-sphere, said moisture sensitive micro-sphere is formed of a moisture sensitive matrix material.

2. The composition of claim 1 wherein said solid nano-spheres are formed of a hydrophobic material.

3. The composition of claim 2 wherein said hydrophobic material is selected from one or more of the group consisting of natural wax, synthetic wax, vegetable wax, natural wax and silicon copolymer, synthetic wax and silicon copolymer, fatty acid esters, fatty alcohols, solid hydrogenated plant oil, natural polymers and synthetic polymers.

4. The composition of claim 1 further comprising a second active agent encapsulated in said moisture sensitive matrix material wherein said moisture sensitive matrix material releases said second active agent upon contact with moisture

5. The composition of claim 1 wherein said hydrophobic material is selected from the group consisting of alkylated polyvinyl pyrolidine, fatty acid esters, fatty alcohols, hydrogenated castor oil, hydrogenated vegetable oil, hard paraffin, hard fat and triglyceride.

6. The composition according to claim 1 wherein said moisture sensitive material is selected from the group consisting of polyvinyl pyrrolidone, water soluble cellulose, polyvinyl alcohol, ethylene maleic anhydride copolymer, methyl vinyl ether maleic anhydride copolymer, polyethylene oxides, polyamide, polyester, copolymers or homopolymers of acrylic acid, polyacrylic acid, polystyrene acrylic acid copolymer, starch derivatives, polyvinyl alcohol, polysaccharide, hydrocolloid, natural gum, protein, and mixtures thereof.

7. The composition of claim 6 wherein said polyvinyl alcohol has a degree of hydrolysis from about 75% to about 99%.

8. The composition of claim 1 wherein said first active agent is one or more of a fragrance, flavor, cosmetic agent, dermatological agent or pharmaceutical agent.

9. The composition of claim 1 wherein said first active agent comprises one or more agents selected from the group consisting of:

anti-oxidants;

free radical scavengers;

moisturizers;

depigmentation agents;

reflectants;

humectants;

antimicrobial agents;

antibacterial agents;

allergy inhibitors;

anti-acne agents;

anti-aging agents;

anti-wrinkling agents, antiseptics;

analgesics;

keratolytic agents;

anti-inflammatory agents;

fresheners;

healing agents;

anti infective agents;

inflammation inhibitors;

wound healing promoters;

peptides, polypeptides;

proteins;

deodorants;

antiperspirants;

skin emollients;

skin moisturizers;

tanning agents;

skin lightening agents;

antiflingals;

depilating agents;

counterirritants;

poison ivy agents;

poison oak agents;

burn products;

make-up preparations;

vitamins;

amino acids and their derivatives;

herbal extracts;

cooling agents;

heating agents;

skin conditioners;

chelating agents;

cell turnover enhancers;

coloring agents;

sunscreens;

nourishing agents;

moisture absorbers;

sebum absorbers; and

skin penetration enhancers.

10. The composition of claim 4 wherein said second active agent is the same or different than said first active agent, said first and second active agents being selected from the group consisting of:

fragrance, flavor, cosmetic agent, dermatological agent and pharmaceutical agent.

11. The composition of claim 10 wherein said first active agent comprises one or more agents selected from the group consisting of:

anti-oxidants;

free radical scavengers;

moisturizers;

depigmentation agents;

reflectants;

humectants;

antimicrobial agents;

antibacterial agents;

allergy inhibitors;

anti-acne agents;

anti-aging agents;

anti-wrinkling agents, antiseptics;

analgesics;

keratolytic agents;

anti-inflammatory agents;

fresheners;

healing agents;

anti infective agents;

inflammation inhibitors;

wound healing promoters;

peptides, polypeptides;

proteins;

deodorants;

antiperspirants;

skin emollients;

skin moisturizers;

tanning agents;

skin lightening agents;

antiflingals;

depilating agents;

counterirritants;

poison ivy agents;

poison oak agents;

burn products;

make-up preparations;

vitamins;

amino acids and their derivatives;

herbal extracts;

cooling agents;

heating agents;

skin conditioners;

chelating agents;

cell turnover enhancers;

coloring agents;

sunscreens;

nourishing agents;

moisture absorbers;

sebum absorbers; and

skin penetration enhancers.

12. The composition of claim 1 wherein said first active agent is present in about 1% to about 80% by weight of said nano-spheres.

13. The composition of claim 4 wherein said first active agent is present in about 1% to about 80% by weight of said nano-spheres and said second active agent is present in about 0.01% to about 60% by weight of said nano-sphere.

14. The composition of claim 1 wherein said moisture sensitive matrix material is formed of polyvinyl alcohol in an amount of about 1% to about 80% by weight of the matrix material.

15. The composition of claim 1 wherein said moisture sensitive matrix material is formed of about 1% to about 80% polyvinyl alcohol by weight of the matrix material and about 1% to about 80% polysaccharide by weight of the matrix material.

16. The composition of claim 1 wherein said micro-sphere has a size of from about 2.0 to about 100 microns.

17. The composition according to claim 1 wherein each of said nano-spheres has an average size of about 0.01 to about 5 microns.

18. The composition according to claim 4 wherein said moisture sensitive material upon contact with said moisture releases said second active agent to provide a burst and said first active agent is released continuously thereafter for an extended period of time.

19. The composition according to claim 18 wherein the extended period of time is in the range of a day to a period of a few weeks.

33. A method for forming the composition of claim 1 comprising the steps of:

incorporating said first active agent into said solid nano-spheres;

forming an aqueous mixture comprising of said solid nano-spheres and said moisture sensitive matrix material; and

spray drying the aqueous mixture to form a dry powder composition.

34. A method for forming the composition of claim 4 comprising the steps of:

heating one or more hydrophobic materials to a temperature above the melting point of the materials to form a melt;

dissolving or dispersing the first active agent into the melt;

dissolving or dispersing a second active agent and said moisture sensitive matrix material in the aqueous phase to form an aqueous composition;

heating the aqueous composition to above the melting temperature of the hydrophobic materials to form a hot melt;

mixing the hot melt with the aqueous phase to form a dispersion;

high shear homogenization of the dispersion at a temperature above the melting temperature until a homogeneous fine dispersion is obtained having a sphere size of from about 1 micron to about 2 microns;

cooling the dispersion to ambient temperature; and

spray drying the emulsified mixed suspension to form a dry powder composition.

20. A anhydrous cosmetic composition comprising a plurality of solid nano-spheres comprising a first active agent said plurality of nano-spheres being encapsulated in a moisture sensitive micro-sphere, said moisture sensitive micro-sphere is formed of a moisture sensitive matrix material.

21. A spray product comprising the composition of claim 20.

22. The spray product of claim 21 further comprising a second active agent, wherein said second active agent is the same or different than said first active agent, said first and second active agent being selected from the group consisting of:

fragrance, flavor, cosmetic agent, dermatological agent and pharmaceutical agent.

23. The spray product of claim 21 wherein said first active agent or said second active agent comprises one or more agents selected from the group consisting of:

anti-oxidants;

free radical scavengers;

moisturizers;

depigmentation agents;

reflectants;

humectants;

antimicrobial agents;

antibacterial agents;

allergy inhibitors;

anti-acne agents;

anti-aging agents;

anti-wrinkling agents, antiseptics;

analgesics;

keratolytic agents;

anti-inflammatory agents;

fresheners;

healing agents;

anti infective agents;

inflammation inhibitors;

wound healing promoters;

peptides, polypeptides;

proteins;

deodorants;

antiperspirants;

skin emollients;

skin moisturizers;

tanning agents;

skin lightening agents;

antifungals;

depilating agents;

counterirritants;

poison ivy agents;

poison oak agents;

burn products;

make-up preparations;

vitamins;

amino acids and their derivatives;

herbal extracts;

cooling agents;

heating agents;

skin conditioners;

chelating agents;

cell turnover enhancers;

coloring agents;

sunscreens;

nourishing agents;

moisture absorbers;

sebum absorbers; and

skin penetration enhancers.

24. The spray product of claim 21 wherein said spray product is a deodorant, antiperspirant, body spray, foot spray, hygiene spray, feminine napkin spray or undergarment spray.

25. A powder product comprising the composition of claim 20.

26. The powder product of claim 25 further comprising a second active agent, wherein said second active agent is the same or different than said first active agent, said first and second active agents being selected from the group consisting of:

fragrance, flavor, cosmetic agent, dermatological agent and pharmaceutical agent.

27. The powder product of claim 25 wherein said first active agent comprises one or more agents selected from the group consisting of:

anti-oxidants;

free radical scavengers;

moisturizers;

depigmentation agents;

reflectants;

humectants;

antimicrobial agents;

antibacterial agents;

allergy inhibitors;

anti-acne agents;

anti-aging agents;

anti-wrinkling agents, antiseptics;

analgesics;

keratolytic agents;

anti-inflammatory agents;

fresheners;

healing agents;

anti infective agents;

inflammation inhibitors;

wound healing promoters;

peptides, polypeptides;

proteins;

deodorants;

antiperspirants;

skin emollients;

skin moisturizers;

tanning agents;

skin lightening agents;

antifungals;

depilating agents;

counterirritants;

poison ivy agents;

poison oak agents;

burn products;

make-up preparations;

vitamins;

amino acids and their derivatives;

herbal extracts;

cooling agents;

heating agents, etc.);

skin conditioners;

chelating agents;

cell turnover enhancers;

coloring agents;

sunscreens;

nourishing agents;

moisture absorbers;

sebum absorbers; and

skin penetration enhancers.

28. The powder product of claim 25 wherein said powder product is a deodorant body powder.

29. A stick product comprising the composition of claim 20.

30. The stick product of claim 29 further comprising a second active agent, wherein said second active agent is the same or different than said first active agent, said first and second active agents being selected from the group consisting of:

fragrance, flavor, cosmetic agent, dermatological agent and pharmaceutical agent.

31. The stick product of claim 29 wherein said first active agent comprises one or more agents selected from the group consisting of:

anti-oxidants;

free radical scavengers;

moisturizers;

depigmentation agents;

reflectants;

humectants;

antimicrobial agents;

antibacterial agents;

allergy inhibitors;

anti-acne agents;

anti-aging agents;

anti-wrinkling agents, antiseptics;

analgesics;

keratolytic agents;

anti-inflammatory agents;

fresheners;

healing agents;

anti infective agents;

inflammation inhibitors;

wound healing promoters;

peptides, polypeptides;

proteins;

deodorants;

antiperspirants;

skin emollients;

skin moisturizers;

tanning agents;

skin lightening agents;

antiflingals;

depilating agents;

counterirritants;

poison ivy agents;

poison oak agents;

bum products;

make-up preparations;

vitamins;

amino acids and their derivatives;

herbal extracts;

cooling agents;

heating agents;

skin conditioners;

chelating agents;

cell turnover enhancers;

coloring agents;

sunscreens;

nourishing agents;

moisture absorbers;

sebum absorbers; and

skin penetration enhancers.

32. The stick product of claim 29 wherein said stick product is a lip balm, lipstick, makeup stick, underarm deodorant stick or underarm antiperspirant stick.