System and method of determining an individualized drug administration protocol

• US 20030220579A1
• Filed: 04/01/2003
• Published: 11/27/2003
• Est. Priority Date: 04/01/2002
• Status: Active Grant

• Current Assignee: Microlife Medical Home Solutions Inc.
• Original Assignee: Microlife Corporation
• Inventors: Mault, James R.
• Granted Patent: US 7,291,114 B2
• Time in Patent Office: Days
• US Class Current: 600/531
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/4872 Body fat
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

A system and method for determining an individualized drug dosage is provided. The system includes a metabolic rate sensing means for sensing the metabolic rate of the individual. The system also includes a computing device having a processor, a memory, an input device, and a display device. The system further includes a data storage means operatively in communication with the processor, and the data storage means includes a drug database containing drug dosage data. The method includes the steps of determining a standardized dosage for a drug. The method also includes the steps of measuring the actual metabolic rate of the individual and determining a metabolic comparison factor by comparing the measured actual metabolic rate to a predetermined standard metabolic rate. The method further includes the steps of adjusting the standardized drug dosage using the comparison factor.

Claims

1. A method of determining an individualized drug dosage for an individual, said method comprising the steps of:

determining a standardized dosage for a drug;

measuring the actual metabolic rate of the individual;

determining a metabolic comparison factor by comparing the measured actual metabolic rate to a predetermined standard metabolic rate; and

adjusting the standardized drug dosage using the comparison factor.

2. The method according to claim 1, wherein said step of measuring the actual metabolic rate of the individual includes using an indirect calorimeter to measure the actual metabolic rate by analyzing the composition of inhalation and exhalation respiratory gases of the individual.

3. The method according to claim 2, wherein the metabolic rate of the individual is measured while the individual is resting.

4. The method according to claim 2, wherein the metabolic rate is measured while the individual is engaged in a physical activity.

5. The method according to claim 1 wherein the standardized drug dosage is based on average body weight.

6. The method according to claim 1 further including the step of administering the adjusted drug dosage to the individual.

7. The method according to claim 1, wherein the adjusted drug dosage includes an amount of the drug relative to a period of time.

8. The method according to claim 1, wherein said step of determining a standardized drug dosage further includes the steps of:

selecting the standardized drug dosage from a drug database containing drug dosage information that is stored in a drug storage means in communication with a computing device having a processor, an input device, a memory and a display device.

9. The method according to claim 8, further including the steps of:

communicating an actual body weight to the computing device; and

communicating the actual metabolic rate to the computing device, wherein the computing device is used to determine the adjusted drug dosage.

10. The method according to claim 8, further including the steps of:

sensing the activity level of the individual using a body activity monitoring means;

transmitting the sensed activity level to the processor;

measuring the active metabolic rate of the individual; and

using the measured active metabolic rate and activity level in determining the metabolic correction factor.

11. The method according to claim 8, further including the steps of:

sensing a body fat level of the individual using a body fat sensing means;

transmitting the sensed body fat level to the processor; and

using the sensed body fat level in determining the comparison factor.

12. The method according to claim 8, further including the step of alerting the individual when to receive the drug using a signaling means operatively in communication with the computing device.

13. The method according to claim 1, further including the steps of:

administering the drug to the individual;

monitoring the change in metabolic rate of the individual over time as the drug is metabolized;

and using the change in metabolic rate in determining a comparison factor for adjusting drug dosage.

14. A method of determining an individualized drug administration protocol for an individual, comprising:

selecting a drug to administer to the individual, wherein the drug is selected from a drug database containing drug dosage information that is stored in a drug storage means in communication with a computing device having a processor, an input device, a memory and a display device;

communicating an actual body weight of the individual to the computing device;

measuring the actual metabolic rate of the individual;

communicating the actual metabolic rate of the individual to the computing device;

determining a comparison factor by comparing the measured actual metabolic rate to a predetermined standard metabolic rate; and

adjusting a predetermined drug dosage for the drug using the comparison factor.

15. The method according to claim 14, further including the step of administering the adjusted drug dosage to the individual.

16. The method according to claim 14, wherein said step of measuring the actual metabolic rate of the individual includes using an indirect calorimeter to measure the actual metabolic rate by analyzing the composition of inhalation and exhalation respiratory gases of the individual.

17. The method according to claim 15, wherein the metabolic rate of the individual is measured while the individual is resting.

18. The method according to claim 15, wherein said metabolic rate is measured while the individual is engaged in a physical activity.

19. The method according to claim 14, further including the steps of:

sensing the activity level of the individual using a body activity monitoring means;

transmitting the sensed activity level to the processor;

measuring the active metabolic rate of the individual; and

using the measured active metabolic rate and activity level in determining the correlation factor.

20. The method according to claim 14, further including the steps of:

sensing a body fat level of the individual using a body fat sensing means;

transmitting the sensed body fat level to the processor; and

using the sensed body fat level in determining the comparison factor.

21. The method according to claim 14, wherein the drug is administered to the individual using a drug delivery device.

22. The method according to claim 14, further includes the step of alerting the individual when to receive the drug using a signaling means operatively in communication with the computing device.

23. The method according to claim 14, further including the steps of:

administering the drug to the individual;

monitoring the change in metabolic rate of the individual over time wherein the metabolic rate changes over time as the drug is metabolized;

and using the change in metabolic rate in determining a comparison factor for adjusting the drug dosage.

24. The method according to claim 23, wherein the drug dosage includes a dosage measured from a time of administering the drug to a time of peak metabolic rate.

25. A system for determining in individualized drug dosage for an individual, comprising:

a metabolic rate sensing means for sensing the metabolic rate of the individual;

a computing device having a processor, a memory, an input device, and a display device;

a data storage means operatively in communication with said processor, wherein said data storage means includes a drug database containing drug dosage data;

wherein said processor utilizes said sensed metabolic rate and standard metabolic rate in determining a comparison factor, and the comparison factor is used to adjust a standard dosage of the drug for the individual.

26. The system according to claim 25, wherein said metabolic rate sensing means is an indirect calorimeter for analyzing the composition of inhalation and exhalation gases of the individual and for producing an output corresponding thereto.

27. The system according to claim 25, further comprising a physical activity sensing means for detecting a physical activity of the individual for use in determining the comparison factor, wherein a signal indicative of the sensed activity level is transmitted to the computing device via a communications link.

28. The system according to claim 25, further comprising:

a body fat sensing means for sensing a body fat percentage of the individual for use in determining the comparison factor, wherein a signal indicative of the sensed body fat is transmitted to the processor via a communications link.

29. The system according to claim 25, further comprising:

a drug delivery means for administering the drug to the individual.

30. The system according to claim 25, further comprising:

an alert device actuated by said processing means for alerting when to administer the drug dosage.

31. The system according to claim 25 wherein the standard metabolic rate is based on an average person of average body weight, height and body fat percentage.

32. The system according to claim 25 wherein the standard drug dosage is determined for an average person of average body weight and average metabolic rate.

33. The system according to claim 25 wherein the computing device is a personal handheld computer.

34. The system according to claim 25 wherein the computing device and the metabolic rate sensing means are contained within a housing.