Implantable or insertable medical devices for controlled drug delivery
First Claim
1. An implantable or insertable medical device comprising:
- (a) a biocompatible polymer; and
(b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent, wherein said medical device is adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion.
2 Assignments
0 Petitions
Accused Products
Abstract
Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.
191 Citations
49 Claims
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1. An implantable or insertable medical device comprising:
- (a) a biocompatible polymer; and
(b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent, wherein said medical device is adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. - View Dependent Claims (2, 3, 4)
- (a) a biocompatible polymer; and
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5. Use of an implantable or insertable medical device, said use comprising reducing pain or discomfort accompanying implantation or insertion of said implantable or insertable medical device, and said implantable or insertable medical device comprising (a) a biocompatible polymer;
- and (b) at lease one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent, and a radio-opacifying agent.
- View Dependent Claims (6, 7, 8)
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9. An implantable or insertable medical device comprising:
- (a) a biocompatible polymer; and
(b) at least one therapeutic agent selected from (i) ketorolac and pharmaceutically acceptable salts thereof and (ii) 4-diethylamino-2-butynylphenylcyclohexylglycolate and pharmaceutically acceptable salts thereof, wherein said medical device is adapted for implantation or insertion at a site that is associated with pain or discomfort upon implantation or insertion. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
- (a) a biocompatible polymer; and
Specification