Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents

  • US 20030232084A1
  • Filed: 04/09/2003
  • Published: 12/18/2003
  • Est. Priority Date: 04/09/1999
  • Status: Active Grant
First Claim
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1. An improved method for administration of a pharmacological composition of the type employing an iron oxide complex with a polyol or polyether, wherein the improvement comprises:

  • administering parenterally an effective dose of an iron oxide complex with a polyol or polyether, the complex formulated in a biocompatible liquid so that upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis; and

    effecting such administration at a rate substantially greater than 1 mL/min.

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