Detection and characterization of cholinergic oscillatory control in peripheral microvasculature and other cardiovascular signals
First Claim
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1. A method of selectively identifying frequency and power of cholinergic oscillatory activity in the microvasculature of a human comprising a). measuring the frequency and power of the oscillatory activity of the human at a frequency from about 0.12 Hz to about 0.18 Hz;
- and b). distinguishing the measured activity obtained in step a) from the sympathetic oscillatory activity and the proximally generated parasympathetic oscillatory activity, thereby selectively identifying the frequency and power of the cholinergic oscillatory activity.
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Abstract
The present invention is an apparatus and method for assessing the condition of a subject by measuring and characterizing one or more oscillatory activities of the subject. The oscillatory activities are under the control of the autonomic nervous system and characterizing the activities provides information related to the status of the autonomic nervous system.
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Citations
30 Claims
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1. A method of selectively identifying frequency and power of cholinergic oscillatory activity in the microvasculature of a human comprising
a). measuring the frequency and power of the oscillatory activity of the human at a frequency from about 0.12 Hz to about 0.18 Hz; - and
b). distinguishing the measured activity obtained in step a) from the sympathetic oscillatory activity and the proximally generated parasympathetic oscillatory activity, thereby selectively identifying the frequency and power of the cholinergic oscillatory activity. - View Dependent Claims (2, 3, 4, 5, 6, 13)
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7. A method of assessing cholinergically mediated oscillatory activity of a subject comprising:
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a). measuring the oscillatory activity of a cardiovascular signal, wherein the measurement comprises data for the frequencies and the powers of the frequencies in the signal;
b). distinguishing the frequencies and the powers of the frequencies from about 0.12 Hz to about 0.18 Hz from the frequencies and the powers of the frequencies from less than 0.12 Hz and from greater than 0.18 Hz so as to obtain the frequencies and the powers of the frequencies from about 0.12 Hz to about 0.18 Hz; and
c). utilizing the frequencies and the powers of the frequencies from about 0.12 Hz to about 0.18 Hz obtained in step b) to assess the cholinergically mediated oscillatory activity of the subject. - View Dependent Claims (8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A system for assessing cholinergically mediated oscillatory activity of a subject comprising:
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a). a device for measuring the oscillatory activity of a cardiovascular signal in the peripheral vasculature, wherein the measurement comprises data for the frequencies and the powers of the frequencies in the signal;
b). a signal processor for distinguishing the frequencies and the powers of the frequencies from about 0.12 Hz to about 0.18 Hz from the frequencies and the powers of the frequencies from less than 0.12 Hz and from greater than 0.18 Hz so as to obtain the frequencies and the powers of the frequencies from about 0.12 Hz to about 0.18 Hz.
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30. A method of diagnosing an autonomic neuropathy in a subject, comprising:
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a). exposing the subject to a physiologic challenge;
b). measuring oscillatory activity of a plurality of blood vessels disposed in a peripheral region of the subject'"'"'s vascular system;
c). determining a power spectrum of the oscillatory signal; and
determining power in a band from about 0.12 Hz to about 0.18 Hz of the power spectrum, wherein the amount of power in the band from about 0.12 Hz to about 0.18 Hz is indicative of an autonomic neuropathy.
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Specification