Aminoacyl trna synthetases
First Claim
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1. An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6, b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6, c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6, and d) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6.
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Abstract
The invention provides human aminoacyl tRNA synthetases (ATRS) and polynucleotides which identify and encode ATRS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ATRS.
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71 Claims
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1. An isolated polypeptide selected from the group consisting of:
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a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6,b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6,c) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6, andd) an immunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO;
1-6. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 57, 58, 59, 60, 61, 62)
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11. An isolated polynucleotide selected from the group consisting of:
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a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO;
7-12,b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO;
7-12,c) a polynucleotide complementary to a polynucleotide of a), d) a polynucleotide complementary to a polynucleotide of b), and e) an RNA equivalent of a)-d). - View Dependent Claims (12, 13, 14, 15, 28, 51, 52, 53, 54, 55, 56, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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Specification