Diagnosis of diseases associated with tumor supressor genes and oncogenes
First Claim
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1. A nucleic acid comprising a sequence at least 18 bases in length of a segment of the chemically pretreated DNA of genes associated with tumor suppressor genes and oncogenes according to one of the sequences taken from the group of Seq. ID No. 1 to Seq. ID No. 536 and sequences complementary thereto.
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Accused Products
Abstract
The present invention relates to the chemically modified genomic sequences of genes associated with tumor suppressor genes and oncogenes, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of tumor suppressor genes and oncogenes which are directed against the sequence, as well as to a method for ascertaining genetic and/or epigenetic parameters of tumor suppressor genes and oncogenes.
25 Citations
32 Claims
- 1. A nucleic acid comprising a sequence at least 18 bases in length of a segment of the chemically pretreated DNA of genes associated with tumor suppressor genes and oncogenes according to one of the sequences taken from the group of Seq. ID No. 1 to Seq. ID No. 536 and sequences complementary thereto.
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2. A nucleic acid comprising a sequence at least 18 bases in length of a segment of the chemically pretreated DNA of genes associated with tumor suppressor genes and oncogenes according to one of the sequences according to one of the genes BRCA2 (U43746), E2F1 (M96577), ELE1 (X71413), MN/CA9 (Z54349), PVT1 (M26714), SAC2 (AK001725), TEM8 (AK025429), TM4SF1 (X01394), TNFSF11 (AF053712), AXL (NM—
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NM—
001699), CCND3 (NM—
001760), CSF1R (NM—
005211), MGMT (NM—
002412), NOV (NM—
002514), SFRS8 (NM—
004592), TNFRSF6 (NM—
000043), TPD52 (NM—
005079), AKT1 (NM—
005163), BCL2 (NM—
000633&
NM—
000657), CBL (NM—
005188), CBLC (NM—
012116), CRK (NM—
005206&
NM—
016823), DCC (NM—
005215), EPHA1 (NM—
005232), EPHA3 (NM—
005233), ETS1 (NM—
005238), ETV5 (NM—
004454), ETV6 (NM—
001987), FGF3 (NM—
005247), FGF4 (NM—
002007), FHIT (NM—
002012), GLTSCR1 (NM—
015711), GPS1 (NM—
004127), GROS1(NM—
022356), HIC1 (NM—
006497), IGFBP7 (NM—
001553), KISS1 (NM—
002256), KRAS2 (NM—
004985), LATS1 (NM—
004690), LOC51213 (NM—
016383), MUC1 (NM—
002456), MUC2 (NM—
002457), N33 (NM—
006765), PTTG1IP (NM—
004339), SE20-4 (NM—
022117), SE70-2 (NM—
022118), SFN (NM—
006142), ST7 (NM—
013437), SUPT3H (NM—
003599), SUPT6H (NM—
003170), TEM1 (NM—
020404), TERT (NM—
003219), THRB NM—
000461), TIMP2 (NM—
003255), TMEFF1 (NM—
003692), TNFAIP6 (NM—
007115), TNFRSF10A (NM—
003844), TNFRSF10B (NM—
003842), TNFRSF10C (NM—
003841), TNFRSF11A (NM—
003840), TNFRSF1A (NM—
001065), TNFSF12 (NM—
003809), TNFSF13 (NM—
003808), TNFSF15 (NM—
005118), TNFSF18 (NM—
005092), TP63 (NM—
003722), TSSC1 (NM—
003310), VDR (NM—
000376), YES1 (NM—
005433), FOXG1A (NM—
004471), GRF2 (NM—
005312), HSPC070 (NM—
014160), RAB3A (NM—
002866), RAB5A (NM—
004162), APC (NM—
000038), BMI1 (NM—
005180), CHES1 (NM—
005197), SMT3H1 (NM—
006936), TIAM1 (NM—
003253), VAV1 (NM—
005428), MCF2 (NM—
005369), MSH2 (NM—
000251), ERBB4 (NM—
005235), FOXG1B (NM—
005249), TACSTD1 (NM—
002354), TRA1 (NM—
003299), FOXG1B (NM—
005249), TACSTD1 (NM—
002354), FLI1 (NM—
002017) and sequences complementary thereto. - View Dependent Claims (7, 8, 9, 11, 12, 13, 14, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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- 3. An oligomer, in particular an oligonucleotide or peptide nucleic acid (PNA)-oligomer, said oligomer comprising in each case at least one base sequence having a length of at least 9 nucleotides which hybridizes to or is identical to a chemically pretreated DNA of genes associated with the cell cycle according to one of the Seq. ID No. 1 through Seq. ID No. 536 and sequences complementary thereto.
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15. A DNA- and/or PNA-array for analyzing diseases associated with the methylation state of genes, comprising at least one nucleic acid according to one of the preceeding claims.
Specification