Implanted sensor processing system and method

• US 20040054385A1
• Filed: 10/21/2003
• Published: 03/18/2004
• Est. Priority Date: 06/29/2000
• Status: Active Grant

• Current Assignee: Senseonics, Incorporated (Senseonics Holdings, Inc.)
• Original Assignee: Jeffery C. Lesho
• Inventors: Lesho, Jeffery C.
• Granted Patent: US 7,553,280 B2
• Time in Patent Office: Days
• US Class Current: 607/60
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence

Abstract

A quantitative measurement system includes an external unit (101a) and an internal unit (102a) are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit (102a) would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit (102a) contains optoelectronics circuitry (102b), a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry (102b) obtains quantitative measurement information and modifies a load (102c) as a function of the obtained information. The load (102c) in turn varies the amount of current through coil (102d), which is coupled to a coil (101f) of the external unit (101a). A demodulator (101b) detects the current variations induced in the external coil (101f) by the internal coil (102d) coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter (101c) and computer interface (101d), for processing the signal into computer-readable format for inputting to a computer (101e).

Claims

1. Apparatus for retrieving information from a sensor device, comprising:

an internal sensor unit for taking quantitative analyte measurements, including a first coil forming part of a power supply for said sensor unit, a load coupled to said first coil, and a sensor circuit for modifying said load in accordance with sensor measurement information obtained by said sensor circuit;

an external unit including a second coil which is mutually inductively coupled to said first coil upon said second coil being placed within a predetermined proximal distance from said first coil, an oscillator for driving said second coil to induce a charging current in said first coil, and a detector for detecting variations in a load on said second coil induced by changes to said load in said internal sensor unit and for providing information signals corresponding to said load changes; and

a processor for receiving and processing said information signals.

2. Apparatus according to claim 1, wherein said sensor circuit comprises an indicator element which emits radiation in proportion to levels of said analyte.

3. Apparatus according to claim 2, wherein said load comprises a photosensitive resistor which receives radiation from said indicator element.

4. Apparatus according to claim 2, wherein said sensor circuit further comprises a radiation source for emitting electromagnetic radiation which stimulates emission of radiation.

5. Apparatus according to claim 2, wherein said indicator element emits fluorescent radiation in proportion to levels of said analyte.

6. Apparatus according to claim 3, wherein said load comprises a photosensitive resistor which receives fluorescent radiation from said indicator element.

7. Apparatus according to claim 4, wherein said radiation source for emitting electromagnetic radiation stimulates emission of fluorescent radiation.

8. Apparatus according to claim 1, wherein said internal unit is implantable in the body of a mammal.

9. Apparatus according to claim 1, wherein said power supply further includes a charging capacitor which is charged by said charging current.

10. Apparatus according to claim 1, wherein said detector of said external unit includes an amplitude modulation (AM) demodulator for detecting changes in amplitude of a voltage waveform caused by changes in said load, said voltage waveform being inductively reflected into said second coil through said first coil.

11. Apparatus according to claim 10, wherein said external unit further includes a pulse counter for converting said detected changes in waveform amplitude into pulses suitable for being converted into computer-readable form.

12. Apparatus according to claim 11, wherein said processor includes a computer.

13. Apparatus according to claim 1, wherein said internal unit is ingestible in the body of a mammal.

14. Apparatus according to claim 1, wherein said internal unit is implantable in the body of a fish.

15. Apparatus according to claim 1, wherein said internal unit is implantable in the body of a plant.

16. Apparatus according to claim 1, wherein said sensor circuit comprises an indicator element which absorbs radiation in proportion to levels of said analyte.

22. Apparatus according to claim 2, wherein said load comprises a photodiode, a comparator and a resistor operatively coupled with each other to provide a varying load as a function of analyte concentration.

17. A sensor device for detecting the presence or concentration of an analyte in a medium, comprising:

an enclosed sensor body having an outer surface surrounding said sensor body;

a radiation source in said sensor body which emits radiation within said sensor body;

an indicator element having an optical characteristic that is affected by the presence or concentration of an analyte, said indicator element being positioned on said sensor body to receive radiation that travels from said radiation source, and which transmits radiation into said sensor body;

a photosensitive element located in said sensor body and positioned to receive radiation within the sensor body from said indicator element; and

an inductive element located in said sensor and coupled to said photosensitive element, said inductive element being adapted to receive from an external inductive element a magnetically induced electric current for supplying power to said sensor device, and being further adapted to induce in said external inductive element an electric current which changes as a function of the amount of radiation received by said photosensitive element.

18. Apparatus for retrieving information from a sensor device, comprising:

an internal sensor unit for taking quantitative analyte measurements, including a first coil forming part of a power supply for said sensor unit, a load coupled to said first coil, and a sensor circuit for modifying said load in accordance with sensor measurement information obtained by said sensor circuit, said sensor circuit including a signal channel detector responsive to analyte measurement information, and a reference channel detector responsive to reference measurement information, outputs of said signal channel detector and said reference channel detector being combined in said sensor information for modifying said load;

an external unit including a second coil which is mutually inductively coupled to said first coil upon said second coil being placed within a predetermined proximal distance from said first coil, an oscillator for driving said second coil to induce a charging current in said first coil, and a detector for detecting variations in a load on said second coil induced by changes to said load in said internal sensor unit and for providing information signals corresponding to said load changes; and

a processor for receiving and processing said information signals.

19. Apparatus according to claim 18, wherein said signal channel detector and reference channel detector are photodiodes.

20. Apparatus according to claim 19, wherein signal channel detector photodiode and said reference channel detector photodiode are connected in a cathode-to-cathode configuration.

21. Apparatus according to claim 18, wherein one of said signal channel detector and said reference channel detector produces an output determinative of a positive transition time of said load modification, and the other produces an output determinative of a negative transition time of said load modification, such that a time difference between a positive load duration and a negative load duration is indicative of analyte concentration as well as a difference between output said reference channel detector and output of said signal channel detector.