Non-invasive apparatus system for monitoring drug hepatoxicity and uses thereof

• US 20040073121A1
• Filed: 10/06/2003
• Published: 04/15/2004
• Est. Priority Date: 10/09/2002
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: Sun, Dehchuan
• Granted Patent: US 7,074,190 B2
• Time in Patent Office: Days
• US Class Current: 600/485
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics

Abstract

The invention relates to a non-invasive apparatus system for monitoring drug hepatotoxicity, and its uses in monitoring drug-induced hepatotoxicity and abnormal liver function.

Claims

1. A non-invasive apparatus system for monitoring drug hepatotoxicity or abnormal liver function comprising:

(a) a sensor for measuring artery blood pressure waveforms to form electric waves representing the artery blood pressure waveforms; and

(b) an analyzer for receiving the electric waves from (a), wherein waveform parameters (including number of wave peaks, major wave peak point, major wave trough point, minor wave peak point, and/or minor trough point), time parameters, pressure parameters, oblique angle parameters, superficial measure parameters, an/or ratio parameters in the electric waves can be calculated by mathematical formulas.

2. The apparatus system according to claim 1, wherein the sensor is a pressure sensory device or one or more electrode chips.

3. The apparatus system according to claim 2, wherein the pressure sensory device is an apparatus worn on wrist to measure the blood pressure waveform of radial artery.

4. The apparatus system according to claim 1, wherein the analyzer further comprises a display device for showing the analyzing data and results recorded in the analyzer.

5. The apparatus system according to claim 1, wherein the analyzer optionally comprises a warning device for emitting warning signals.

6. The apparatus system according to claim 1, wherein the analyzer further comprises an apparatus, which can transfer the measured and analyzed data to a terminal at hospital'"'"'s or doctor'"'"'s end, and the apparatus can further receive the signals transferred from the hospital or doctor.

7. The apparatus system according to claim 6, wherein the signal is transferred in a wire or wireless way.

9. A method for monitoring hepatotoxicity or drug induced abnormal liver function, the method comprising:

the utilization of the apparatus system according to any one of claims 1 to 8 in monitoring and calculating the blood pressure waveform wave form parameter (including number of wave peaks, major wave peak point, major wave trough point, minor wave peak point, and/or minor wave trough point), time parameters, pressure parameters, oblique angle parameters, superficial measure parameters, and/or ratio parameters before and after taking a drug;

if the altered amounts of any or some of the parameters before and after taking the drug are lower than a certain preset value, it means that the drug does not induce liver function side effect;

if the altered amounts of any or some of the parameters are between two certain preset values, it means that the drug has induced a certain level of liver function change;

if the altered amounts of any or some of the parameter values are higher than a preset value, it means that the drug has induced a severe liver function change.

8. A non-invasive apparatus system for monitoring drug hepatotoxicity or abnormal liver function comprising:

a wrist type sphygmomanometer which uses a pressure sensory element to transform the radial artery blood pressure waveform of the patient'"'"'s arm to waveform parameters (including number of wave peak, major wave peak point, major wave trough point, minor wave peak point, and/or minor wave trough point), time parameters, pressure parameters, oblique angle parameters, superficial measure parameters, and/or ratio parameters;

a bedside recording analyzer which can receive, amplify, filter, and analog-digital transform the electric wave from the sphygmomanometer, wherein the analyzer comprises a small computer to record blood pressure waveform and analyze the frequency, amplitude of vibration, and angles; and

an information server and a terminal machine which can send the information from the analyzer to a hospital or clinic for determining by a doctor, and send back instructions from the doctor to the patient'"'"'s bedside record analyzer.