N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders

• US 20040082639A1
• Filed: 05/14/2003
• Published: 04/29/2004
• Est. Priority Date: 05/15/2002
• Status: Active Grant

• Current Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Original Assignee: Janssen Pharmaceutica NV (Johnson & Johnson)
• Inventors: Ho, Chih Yung, Strobel, Eric D., Emanuel, Stuart, Johnson, Dana L., Ludovici, Donald W., Sechler, Jan L., Tuman, Robert W., Mei, Jay M., Yen, Hwa Kwo, Galemmo, Robert A. Jr., Maharoof, Umar, Brunmark, Bengt Anders
• Granted Patent: US 7,196,110 B2
• Time in Patent Office: Days
• US Class Current: 514/405
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 231/54 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 231/56 Benzopyrazoles; Hydrogenated benzopyrazoles
• CPC Class Codes: C07D 233/64 with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 405/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 413/12 : linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 491/04 : Ortho-condensed systems
• CPC Class Codes: C07D 495/04 : Ortho-condensed systems
• CPC Class Codes: C07F 9/65038 : condensed with carbocyclic rings or carbocyclic ring systems

Abstract

The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.

Claims

1. A compound of Formula (I):

2. A compound as in claim 1 of the formula (Ia)

3. A compound as in claim 1 wherein

n is an integer from 1 to 2;

R¹ is hydrogen;

is selected from the group consisting of phenyl, a five to six membered heteroaryl and a nine to ten membered benzo-fused heterocycloalkyl group;

wherein the nine to ten membered benzo-fused heterocycloalkyl group is attached to the molecule such that the phenyl ring is bound directly to the

portion of the molecule;

p is an integer from 0 to 2;

R² is selected from the group consisting of di(lower alkyl)amino-alkoxy, lower alkyl-alkoxy, hydroxy substituted alkoxy and

wherein A¹ is selected from the group consisting of lower alkyl;

wherein the lower alkyl is optionally substituted with one to two substituents independently selected from hydroxy, amino, alkylamino or dialkylamino; and

wherein

is selected from the group consisting of a five or six membered heteroaryl and a five or six membered heterocycloalkyl;

wherein the heteroaryl or heterocycloalkyl is optionally substituted with one to two substituents independently selected from halogen, lower alkyl, lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino;

q is an integer from 0 to 2;

R³ is selected from the group consisting of lower alkyl and lower alkoxy, and halogen;

L¹ is absent or lower alkyl;

is selected from the group consisting of phenyl and a five or six membered heteroaryl group;

wherein the phenyl or heteroaryl group is optionally substituted with one to two substituents independently selected from halogen, lower alkyl, lower alkoxy or benzyloxy;

or an optical isomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salt thereof.

4. A compound as in claim 1 wherein

n is an integer from 1 to 2;

R¹ is hydrogen;

is selected from the group consisting of phenyl, thienyl and 1,3-benzodioxolyl;

p is an integer from 0 to 2;

R² is selected from the group consisting of 3-dimethylamino-propoxy, 3-methoxy-propoxy, 2,3-dihydroxy-n-propoxy, 3-hydroxy-propoxy, 2-hydroxy-3-pyrrolidin-1-yl-propoxy and 3-(4-methyl-piperazin-1-yl-propoxy;

q is an integer from 0 to 2;

R³ is selected from the group consisting of methyl, methoxy, ethoxy.

L¹ is absent or CH₂;

is selected from the group consisting of phenyl and pyridyl;

wherein the phenyl is optionally substituted with one to two substituents independently selected from fluoro, chloro, methyl, methoxy or benzyloxy;

or an optical isomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salt thereof.

5. A compound as in claim 1 wherein

6. A compound as in claim 5, wherein

44. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43.

45. A pharmaceutical composition made by mixing a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 and a pharmaceutically acceptable carrier.

46. A process for making a pharmaceutical composition comprising mixing a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 and a pharmaceutically acceptable carrier.

47. A method of treating a disorder related to PDGF receptor or a cell proliferative disorder in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43.

48. A method of treating a cell proliferative disorder or a disorder related to PDGF receptor in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the composition of claim 44.

49. The method of claim 48 wherein said cell proliferative disorder is a neoplastic disorder.

50. The method of claim 49 wherein said the neoplastic disorder is a cancer selected from the group consisting of a glioma cancer, a lung cancer, a breast cancer, a colorectal cancer, a prostate cancer, a gastric cancer, an esophageal cancer, a colon cancer, a pancreatic cancer, an ovarian cancer, a melanoma, a myelodysplasia, a multiple myeloma, a lymphoma, and a leukemia.

51. The method of claim 50 wherein said leukemia is selected from chronic myelogenous leukemia (CML);

acute lymphocytic leukemia (ALL);

chronic neutrophilic leukemia (CNL);

acute undifferentiated leukemia (AUL); and

acute myelogenous leukemia (AML).

52. The method of claim 48 wherein said cell proliferative disorder is not a neoplastic disorder.

53. The method of claim 52 wherein said cell proliferative disorder is selected from atherosclerosis, transplantation-induced vasculopathies, neointima formation, lung fibrosis, macular degeneration, restenosis, pulmonary fibrosis, glomerulonephritis, glomerulosclerosis, congenital multicystic renal dysplasia, kidney fibrosis, diabetic retinopathy and rheumatoid arthritis.

54. A method for treating a cell proliferative disorder or a disorder related to PDGF receptor in a subject in need thereof comprising administration of a therapeutically effective amount of a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 in combination with one or more therapies choosing from the group consisting of a chemotherapy, a radiation therapy, a gene therapy, and an immunotherapy.

55. A method of treating a cell proliferative disorder or a disorder related to PDGF-R in a subject in need thereof comprising the controlled delivery, by release from an intraluminal medical device, of a therapeutically effective amount of a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43.

56. The method of claim 55 wherein said cell proliferative disorder or a disorder related to PDGF-R is restenosis, intimal hyperplasia, atherosclerosis or inflammation, in vessel walls.

57. A drug delivery device comprising an intraluminal medical device, and a therapeutically effective amount of a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43.

58. The drug delivery device of claim 57, wherein the intraluminal medical device is a stent.

59. A method of treating a cell proliferative disorder or a disorder related to PDGF receptor in a subject in need thereof, comprising administering to the subject a therapeutic effective amount of a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 conjugated to a targeting agent.

60. The method of claim 59, wherein said cell proliferative disorder is a neoplastic disorder selected from a glioma cancer, a lung cancer, a breast cancer, a colorectal cancer, a prostate cancer, a gastric cancer, an esophageal cancer, a colon cancer, a pancreatic cancer, an ovarian cancer, a melanoma, a myelodysplasia, a multiple myeloma, a leukemia and a lymphoma.

61. A pharmaceutical composition comprising a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 conjugated to a targeting agent and a pharmaceutically acceptable carrier.

62. A pharmaceutical composition made by mixing a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 conjugated to a targeting agent and a pharmaceutically acceptable carrier.

63. A process for making a pharmaceutical composition comprising mixing a compound of claims 1, 7, 20, 22, 24, 26, 28-30, 32, 34, and 36-43 conjugated to a targeting agent and a pharmaceutically acceptable carrier.

7. A compound of Formula (II):

8. A compound as in claim 7 wherein:

9. A compound as in claim 7 wherein:

10. A compound as in claim 7 wherein:

L² is a linking group selected from the group consisting of;

—

(CH₂)—

, —

(CH₂)_3-4—

, —

CH(R¹⁰⁰)—

, —

C(═

R¹⁰⁰)—

, —

C(R¹⁰⁰)₂—

, —

O(CH₂)_1-4—

, —

OCH(R²⁰⁰)—

, —

OC(R¹⁰⁰)₂—

, —

NH—

, —

N(lower alkyl)-, —

N(COalkyl)-, —

N(aryl)-, —

N(CO₂alkyl)-, —

N(CONHalkyl)-, —

N(SO₂alkyl) and —

N(SO₂aryl)-;

wherein R²⁰⁰ is selected from;

alkyl, hydroxy, aryl, oxo, —

NH₂, —

NH(alkyl) -N(alkyl)₂, ═

N(OH) or —

NH₂OH.

11. A compound as in claim 7 wherein:

R⁹ and R¹⁰ are independently selected from the group consisting of;

1-piperidinyl, 2-(pyrrolidin-1-yl)-ethoxy, 2,3-dihydroxy-propoxy, 2-hydroxy-3-pyrrolidin-1-yl-propoxy, 3-(4-methyl-piperazin-1-yl)-propoxy, 3-(N,N-dimethyl-amino)-propoxy, 3-hydroxy-propoxy, 3-imidazol-1-yl-propoxy, 3-methoxy-propoxy, 3-morpholin-4-yl-propoxy, 3-pyrrolidin-1-yl-2-hydroxy-propoxy, 3-pyrrolidin-1-yl-propoxy, 4-methyl-piperazin-1-yl, amino, benzyl, benzyloxy, bromo, chloro, cyano, ethoxy, fluoro, H, hydroxy, isopropoxy, methoxy, methyl, N-(1-oxo-ethyl)-amino, and N,N-dimethyl-amino.

12. A compound as in claim 7 wherein:

R⁶ and R⁷ are independently selected from the group consisting of;

(a)

(b)

provided that R⁴ is not

(c) —

CH₂—

substituted with one group selected from;

—

H, -methyl, —

Oalkyl, —

CH₂OH, —

CH(CH₃)OH, —

O(C═

O)alkyl, —

C(═

O)Oalkyl, —

(C═

O)NH₂, —

C(═

O)alkyl or -phenyl-OC(═

O)alkyl;

(f) —

C(═

O)alkyl optionally substituted with one or more groups independently selected from;

—

OH, —

Oalkyl, —

Oalkyl-phenyl or —

OC(═

O)alkyl;

(g) —

C(═

O)phenyl optionally substituted with one or more groups independently selected from;

—

Oalkyl, chloro or fluoro,;

(h) —

C(═

O)(CH₂)_1-6C(═

O)—

terminating with —

OH, —

Oalkyl, —

NH₂, —

NHalkyl, —

N(alkyl)₂, or pyrrolidinyl;

(hh) —

C(═

O)alkylOC(═

O)alkyl-terminating with —

Oalkyl;

(i) —

C(═

O)O(CH₂CH₂O—

)_1-10 terminating with H or benzyl;

(j) —

C(═

O)Oalkyloptionally substituted with one or more —

Oalkyl groups;

(k) —

C(═

O)Ophenyl optionally substituted with one or more chloro, fluoro groups;

(l) —

C(═

O)NH(CH₂CH₂O—

)_1-10 terminating with —

H;

(m) —

C(═

O)NH(C_1-20)alkyl optionally substituted with one or more groups independently selected from;

—

NH₂, —

NHalkyl, —

N(alkyl)₂, pyrrolidinyl, morpholinyl, —

NHC(═

O)alkyl, —

OC(═

O)alkenyl, —

NHC(═

O)phenyl or —

C(═

O)Oalkyl; and

, wherein the phenyl portion of said —

NHC(═

O)phenyl may be optionally substituted with one or more groups independently selected from;

alkyl, —

OH, —

Oalkyl, —

NH₂, —

NHalkyl, —

N(alkyl)₂, halogen and nitrile;

(n) —

C(═

O)NHphenyl optionally substituted with one or more fluoro groups;

(o) —

C(═

O)NHCH₂CH₂NH(CH₂CH₂NH—

)_0-3 terminating with —

CH₂CH₂OH and —

C(═

O)phenyl;

wherein the phenyl portion of said —

C(═

O)phenyl may be optionally substituted with one or more —

OHgroups;

(p) —

C(═

S)NH₂;

(u) —

SO₂N(alkyl)₂; and

(w) —

P(═

O)(OCH₂CH₃)₂;

provided that when R⁶ is present, R⁷ is absent; and

provided that when R⁷ is present, R⁶ is absent.

13. A compound as in claim 7 wherein:

R⁶ and R⁷ are independently selected from the group consisting of;

H,

14. A compound as in claim 7 wherein:

L³ is absent or is a linking group selected from the group consisting of methylene, ethylene or carbonyl.

15. A compound as in claim 7 wherein:

16. A compound as in claim 7 wherein:

R⁵ is independently selected from the group consisting of;

methyl, ethyl, isopropyl, t-butyl, methoxy, ethoxy, —

C(═

O)NH₂, —

C(═

O)Omethyl, —

C(═

O)Oethyl, —

C(═

O)OH, cyano, dimethyl-amino, bromo, chloro, fluoro, trifluoromethyl, trifluoromethoxy, thio-trifluoromethyl, hydroxy, hydroxymethyl, hydroxyethyl, nitro, —

SO₂NH₂, thiomethyl

17. A compound as in claim 16 wherein:

V and W are each independently absent or selected from the group consisting of;

—

C(═

O), —

C(═

O)N(alkyl)-, —

C(═

O)NH—

, —

C(═

O)O—

, —

NH—

, —

O— and

—

SO₂—

;

B¹⁰ is absent or selected from methyl or ethyl,;

wherein methyl or ethyl are optionally substituted with one or more groups independently selected from dimethyl-amino or hydroxy; and

B²⁰ is absent or selected from alkyl, alkenyl, or H, wherein, when B²⁰ is alkyl or alkenyl, the alkyl or alkenyl group may be optionally substituted with one or more groups independently selected from;

alkoxy, alkylamino, amino, dialkylamino, halogen, halogenated alkoxy, hydroxy, —

NHC(═

O)NH₂, —

NHSO₂alkyl or thioalkyl.

18. A compound as in claim 17 wherein:

19. A compound as in claim 9 wherein:

27. A compound as in claim 16 wherein R¹⁰⁰ is selected from the group consisting of:

H, methyl, and ethyl;

R^B is selected from the group consisting of;

methoxy and ethoxy; and

R⁵ is selected from the group consisting of;

methoxy, ethoxy, isopropoxy, chloro, methyl, cyano and hydroxy.

20. A compound of Formula (II-AA):

21. A compound as in claim 20, wherein R¹⁰⁰ is selected from the group consisting of:

H, methyl, ethyl;

R^B and R^C are independently selected from the group consisting of;

methoxy and ethoxy; and

R⁵ is selected from the group consisting of;

methoxy, ethoxy, isopropoxy, chloro, bromo, and fluoro.

22. A compound of Formula (II-BB):

23. A compound as in claim 22, wherein R¹⁰⁰ is selected from the group consisting of:

H, methyl, ethyl;

R^B is selected from the group consisting of;

methoxy and ethoxy; and

R⁵ is selected from the group consisting of;

methoxy, ethoxy, isopropoxy, chloro, bromo, and fluoro.

24. A comound of Formula (II-CC)

25. A compound as in claim 24 wherein R¹⁰⁰ is selected from the group consisting of:

H, methyl, ethyl;

R^B and R^C are independently selected from the group consisting of;

methoxy and ethoxy; and

R⁵ is selected from the group consisting of;

methoxy, ethoxy, isopropoxy, chloro, methyl, cyano and hydroxy.

26. A comound of Formula (II-DD)

28. A comound of Formula (II-EE)

29. A compound of Formula (II-FF)

30. A compound of Formula (II-GG):

31. A compound as in claim 30, wherein R⁷ is absent, and R6 is selected from the group consisting of:

(a)

(b)

provided that R⁴ is not

(c) methyl

(d) —

C(═

O)CH₂OH; and

(e) —

C(═

O)CH₂Omethoxy;

32. A compound of Formula (II-HH):

33. A compound as in claim 32, wherein L² is a linking group selected from the group consisting of:

—

(CH₂)—

, —

CH(CH₃)—

, —

CH(CH₂CH₃)—

.

34. A compound of Formula (II-JJ):

35. A compound selected from the group consisting of:

36. A compound selected from the group consisting of:

37. A compound of the following formula:

38. A compound of the following formula:

39. A compound of the following formula:

40. A compound of the following formula:

41. A compound selected from the group consisting of:

1-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

[7-Methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

1-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

(3-Bromo-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

1-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

(3-Methoxy-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2,6-Dichloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

1-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2-Chloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;

3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

1-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

(2-Bromo-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Bromo-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

1-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;

1-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

(3-Chloro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-phenyl)-amine;

3-[7-(3-Hydroxy-propoxy)-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(3-Chloro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methylsulfanyl-phenyl)-amine;

(3-Fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Chloro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

1-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(3-Fluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Difluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

(3-Fluoro-phenyl)-(4-methoxy-2-methyl-8a,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-amine;

1-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzamide;

(3-Chloro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-ol;

3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

{7-Methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-(3-methoxy-phenyl)-amine;

(3-Fluoro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;

[6-(3-Dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-methoxy-ethanone;

1-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(3-Fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;

(2,6-Difluoro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

1-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Chloro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

[5-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(3-Bromo-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

Methoxy-acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(3,5-Difluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Ethoxy-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

1-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-isopropoxy-phenyl)-amine;

3-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[7-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;

3-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

N3-(3-Fluoro-phenyl)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazole-3,5-diamine;

(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;

[6-(3-Methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-phenyl-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(3-Fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-[7-(3-Hydroxy-propoxy)-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid methyl ester;

(2,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

(3-Bromo-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(2,5-Dichloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;

(3-Chloro-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

Acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

(7-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(2-Chloro-benzyl )-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

1-[3-(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-fluoro-phenyl)-amine;

(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

N3-(3-Chloro-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

1-[3-(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

N3-(3-Methoxy-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

3-[3-(3-Ethoxy-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyramide;

(4-Methoxy-2-methyl-6,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-(3-methoxy-phenyl)-amine;

(7-Methoxy-2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-phenyl-amine;

3-[3-(2-Methyl-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;

(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

3-[7-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2,6-Dichloro-benzyl)-[5-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-(3-Fluoro-phenylamino)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-4-fluoro-phenyl)-amine;

(5-Chloro-2-methoxy-phenyl)-(2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(4-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-methoxy-phenyl)-amine;

(2,6-Dichloro-benzyl )-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

Butyric acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;

5-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-5-oxo-pentanoic acid methylamide;

1-[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(3-Fluoro-phenyl)-(5-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-4-methoxy-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenol;

4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyric acid;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-yl]-3-pyrrolidin-1-yl-propane-1,3-dione;

N-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethyl-phenyl)-amine;

[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-methanol;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3,5-dimethoxy-phenyl)-amine;

(3-Benzyloxy-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(6,7-Diisopropoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-fluoro-phenyl)-amine;

3-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-3-oxo-propionic acid ethyl ester;

3-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-trifluoromethyl-phenyl)-amine;

(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;

(3,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-hydroxy-ethanone;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(5,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-(3-methoxy-phenyly-amine;

(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(2,5-dimethoxy-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-2-carboxylic acid 4-fluoro-phenyl ester;

3-[3-(3-Chloro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;

3-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

(3,4-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[3-(3-Bromo-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propane-1,2-diol;

(2,5-Difluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-trifluoromethylsulfanyl-phenyl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-trifluoromethyl-phenyl)-amine;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(5-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(2,9-Dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-(3-methoxy-phenyl)-amine;

(2,3-Dimethoxy-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;

3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-phenyl)-amine;

[6-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-phenyl)-(2,9-dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(1H-indol-5-yl)-amine;

(3-Chloro-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Chloro-4-fluoro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

(3-Bromo-phenyl)-(2,9-dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-amine;

Isobutyric acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

(5,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-(3-ethoxy-phenyl)-amine;

(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid ethyl ester;

(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6,7-Diisopropoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(2,5-Difluoro-phenyl)-(6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-benzyl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Bromo-phenyl)-(6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Bromo-phenyl)-(6,7-diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-benzyl)-amine;

(1H-Indol-5-yl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-yl]-ethanone;

(2,9-Dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-trifluoromethyl-benzyl)-amine;

Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-ylmethyl ester;

(3-Chloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

(4-Ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

3-[(6,7-Dimethoxy-3-phenylamino-4H-indeno[1,2-c]pyrazole-2-carbonyl)-amino]-propionic acid ethyl ester;

(2,5-Difluoro-phenyl)-(4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-2-yl-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

Benzyl-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-phenyl)-(5,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-amine;

(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

(7-Benzyloxy-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6-Bromo-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

N3-Phenyl-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid 4-chloro-phenyl ester;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-benzyl)-amine;

3-[3-(2,6-Difluoro-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;

(3-Methoxy-phenyl)-[6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine; and

[6-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(4-fluoro-phenyl)-amine.

42. A compound selected from the group consisting of:

(5-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid methyl ester;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-trifluoromethyl-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;

[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-methanol;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenol;

(7-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3,5-dimethoxy-phenyl)-amine;

(3-Bromo-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Benzyloxy-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

[5-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(2,9-Dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-(3-methoxy-phenyl)-amine;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzamide;

N3-(3-Methoxy-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

N3-(3-Chloro-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

(3-Bromo-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-phenyl)-(2,9-dihydro-5,7-dioxa-2,3-diaza-cyclopenta[a]-s-indacen-1-yl)-amine;

[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;

(3-Bromo-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

(3-Chloro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

[6-(3-Methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-phenyl-a mine;

(3-Methoxy-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-[7-Methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;

[6-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(6,7-Diisopropoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(4-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Fluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Difluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

(6-Chloro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

[6-(3-Dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-4-fluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3,5-Dimethoxy-phenyl )-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3,4-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3,5-Difluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methylsulfanyl-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-ethyl-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-trifluoromethylsulfanyl-phenyl)-amine;

(3-Chloro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl )-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;

{7-Methoxy-6-[3-(4-methyl-piperazin-1-yl )-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-(3-methoxy-phenyl)-amine;

(3-Fluoro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl )-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;

(3-Fluoro-phenyl )-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-4-fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(2-Chloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(5,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-(3-methoxy-phenyl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-methoxy-phenyl)-amine;

(2,5-Difluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-trifluoromethyl-phenyl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

[7-Methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

1-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

1-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-phenyl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-4-fluoro-phenyl)-amine;

1-[3-(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(2-Chloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,6-Dichloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(3-Chloro-4-methoxy-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

1-[3-(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(2,6-Difluoro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,3-Dimethoxy-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Dichloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(2,5-dimethoxy-phenyl)-amine;

(5-Chloro-2-methoxy-phenyl)-(2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(3-Bromo-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-ol;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

3-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[3-(3-Chloro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

3-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[7-(3-Hydroxy-propoxy)-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Chloro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;

3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

(3-Fluoro-phenyl )-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;

3-[7-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

1-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(3-Fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-(3-Hydroxy-propoxy)-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Ethoxy-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2,6-Dichloro-benzyl)-[5-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Fluoro-phenyl)-(5-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-hydroxy-ethanone;

3-[3-(3-Chloro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;

3-[3-(2-Methyl-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;

3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-3-oxo-propionic acid ethyl ester;

1-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-methoxy-ethanone;

4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyric acid;

Acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

3-[3-(3-Bromo-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propane-1,2-diol;

Methoxy-acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

Butyric acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;

Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-ylmethyl ester;

Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-ylmethyl ester;

3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-2-carboxylic acid 4-fluoro-phenyl ester;

5-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-5-oxo-pentanoic acid methylamide;

3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazole-1-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;

4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyramide;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-2-yl]-3-pyrrolidin-1-yl-propane-1,3-dione;

(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Ethoxy-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

N-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl]-acetamide;

N3-(3-Fluoro-phenyl)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazole-3,5-diamine;

(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(4-Methoxy-2-methyl-6,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-(3-methoxy-phenyl)-amine;

(2-Bromo-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-amine;

(5-Bromo-pyridin-2-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-isopropoxy-phenyl)-amine;

(2,6-Dichloro-benzyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-fluoro-phenyl)-amine;

(7-Methoxy-2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-phenyl-amine;

(3-Fluoro-phenyl)-(4-methoxy-2-methyl-8a,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-amine; and

,

3-(3-Fluoro-phenylamino)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol.

43. A compound selected from the group consisting of:

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzoic acid methyl ester;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;

(7-Methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

(3-Bromo-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

[5-(3-Dimethylamino-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

3-(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-benzamide;

N3-(3-Methoxy-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

N3-(3-Chloro-phenyl)-2,4-dihydro-indeno[1,2-c]pyrazole-3,6-diamine;

(3-Bromo-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-phenyl)-[6-(4-methyl-piperazin-1-yl)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Bromo-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

[7-Methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

(3-Chloro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

[6-(3-Methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-phenyl-amine;

(3-Methoxy-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

3-[7-Methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino]-benzoic acid methyl ester;

(4-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Fluoro-phenyl)-(7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrrolidin-1-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Fluoro-phenyl)-(7-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

[6-(3-Dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Chloro-4-fluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Dimethoxy-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3,5-Difluoro-phenyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methylsulfanyl-phenyl)-amine;

(3-Chloro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;

{7-Methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-(3-methoxy-phenyl)-amine;

(3-Fluoro-phenyl)-{7-methoxy-6-[3-(4-methyl-piperazin-1-yl)-propoxy]-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-amine;

(3-Fluoro-phenyl)-[6-(3-imidazol-1-yl-propoxy)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(2-Chloro-benzyl )-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Difluoro-phenyl)-(6-fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-m-tolyl-amine;

(3-Fluoro-phenyl)-[7-methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

[7-Methoxy-6-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(3-Bromo-phenyl )-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

1-[3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[7-Methoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[7-Methoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(3-Chloro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-fluoro-phenyl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-methoxy-phenyl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-(3-chloro-phenyl)-amine;

[6,7-Bis-(3-methoxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-pyridin-3-yl-amine;

1-[3-(6-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(2-Chloro-benzyl )-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,6-Dichloro-benzyl)-(6,7-diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-phenyl-amine;

1-[3-(7-Methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-ylamino)-phenyl]-ethanol;

(2,6-Difluoro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(2,5-Dichloro-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-amine;

(7-Fluoro-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(2,4-Dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6,7-Diethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(3-Bromo-phenyl)-(6-fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(4-fluoro-phenyl)-amine;

3-(3-Fluoro-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-ol;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridin-3-yl-amine;

3-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

3-[3-(3-Chloro-phenylamino)-6-ethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol;

(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(6-Bromo-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-methoxy-phenyl)-amine;

3-[7-(3-Hydroxy-propoxy)-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Chloro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl )-(3-ethoxy-phenyl)-amine;

3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2-Chloro-pyridin-3-yl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

3-[3-(3-Ethoxy-phenylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

(3-Fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;

(3-Chloro-4-fluoro-phenyl)-(2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl)-amine;

3-[7-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(3-Chloro-4-fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

1-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(2-Fluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

3-[3-(3-Fluoro-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[7-(3-Hydroxy-propoxy)-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(3-Ethoxy-phenylamino)-7-(3-hydroxy-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

(2,6-Dichloro-benzyl)-[5-(3-morpholin-4-yl-propoxy)-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-amine;

(3-Fluoro-phenyl)-(5-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6-Fluoro-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(2-methyl-benzyl)-amine;

3-[3-(2-Methyl-benzylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-5-yloxy]-propan-1-ol;

3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propan-1-ol;

3-[3-(2,6-Dichloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(2-Chloro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

3-[3-(2,6-Difluoro-benzylamino)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,2-diol;

1-[6-Ethoxy-3-(3-fluoro-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[6-Ethoxy-3-(pyridin-3-ylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[6-Ethoxy-3-(3-methoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[6-Ethoxy-3-(3-ethoxy-phenylamino)-2,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-3-pyrrolidin-1-yl-propan-2-ol;

1-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-methoxy-ethanone;

Acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

Methoxy-acetic acid 2-[3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-2-oxo-ethyl ester;

Acetic acid 3-(3-fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl methyl ester;

4-[3-(3-Fluoro-phenylamino)-6,7-dimethoxy-4H-indeno[1,2-c]pyrazol-1-yl]-4-oxo-butyramide;

(3-Bromo-phenyl)-(6,7-dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-4-methyl-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-ethoxy-phenyl)-amine;

(3-Bromo-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(3-Ethoxy-phenyl)-(4-ethyl-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

N3-(3-Fluoro-phenyl)-6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazole-3,5-diamine;

(4-Methoxy-2-methyl-6,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-(3-methoxy-phenyl)-amine;

(2-Bromo-benzyl)-(6,7-dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-amine;

(6,7-Dimethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-isopropoxy-phenyl)-amine;

(6,7-Diethoxy-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine;

(7-Methoxy-2H-8-oxa-2,3-diaza-cyclopenta[a]inden-1-yl )-phenyl-amine;

(3-Fluoro-phenyl)-(4-methoxy-2-methyl-8a,9-dihydro-3-oxa-1,6,7-triaza-cyclopenta[b]-as-indacen-8-yl)-amine; and

3-(3-Fluoro-phenylamino)-6-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-7-ol.

64. A method of identifying novel PDGF-R kinase inhibitors comprising the steps of:

(a) determining a three-dimensional structure of the compound of Fomula I or II in the absence or presence of a polypeptide comprising the PDGF-R kinase catalytic domain;

(b) analyzing the three-dimensional structure for the compound alone or for the intermolecular interaction between said compound and PDGF-R;

(c) selecting a compound that mimics the structure for the compound alone or incorporates the predictive interaction;

(d) synthesizing said designed compound; and

(e) determining the ability of the molecule to bind and inhibit PDGF-R kinase activity.

65. A method of identifying novel c-Abl kinase inhibitors comprising the steps of:

(a) determining a three-dimensional structure of the compound of Fomula I or II in the absence or presence of a polypeptide comprising the c-Abl kinase catalytic domain;

(b) analyzing the three-dimensional structure for the compound alone or for the intermolecular interaction between said compound and c-Abl;

(c) selecting a compound that mimics the structure for the compound alone or incorporates the predictive interaction;

(d) synthesizing said designed compound; and

(e) determining the ability of the molecule to bind and inhibit c-Abl kinase activity.

66. A method for reducing or inhibiting the PDGF-R kinase activity in a cell comprising the step of contacting the cell with a compound of Formula (I) or (II).

67. A method for reducing or inhibiting the PDGF-R kinase activity in a subject coprising the step of administering to the subject a compound of Formula (I) or (II).

68. A method for reducing or inhibiting the c-Abl kinase activity in a cell comprising the step of contacting the cell with a compound of Formula (I) or (II).

69. A method for reducing or inhibiting the c-Abl kinase activity in a subject comprising the step of administering to the subject a compound of Formula (I) or (II).

70. A method of inhibiting cell proliferation in a cell comprising the step of contacting the cell with a compound of Formula (I) or (II).

71. A process for the preparation of a compound of Formula (I):

72. The process of claim 71, further comprising

73. The process of claim 72, further comprising

74. A process for the preparation of a compound of formula (S5)

75. A process for the preparation of a compound of formula (S3)

76. A process for the preparation of a compound of Formula (IIa):

77. The process of claim 76, further comprising

78. The process of claim 77, further comprising

79. A process for the preparation of a compound of formula (T5)

80. A process for the preparation of a compound of formula (T3)