Analyte measurement
First Claim
1. A device for measuring the concentration of an analyte in a fluid, comprising a support member and a plurality of analyte sensing means provided thereon for measuring said concentration, wherein said device further comprises a plurality of conduits such that each of said sensing means has a conduit associated therewith, said conduits serving in use to direct said fluid to respective sensing means.
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Accused Products
Abstract
A glucose sensor in the form of a skin patch 2 has a microneedle 4 which painlessly penetrates the skin to draw out interstitial fluid. The interstitial fluid passes to a common entrance port 7. A series of microchannels 8 is provided on the skin patch. The fluid drawn onto the patch is selectively switched between a number of microchannels 8 by means of electro-osmotic pumps 10 and hydrophobic gates 12. Each microchannel 8 has an electrochemical detector 11 for sensing gluocse concentration.
Also disclosed is a monlithic device with an integrated lance 83.
537 Citations
176 Claims
- 1. A device for measuring the concentration of an analyte in a fluid, comprising a support member and a plurality of analyte sensing means provided thereon for measuring said concentration, wherein said device further comprises a plurality of conduits such that each of said sensing means has a conduit associated therewith, said conduits serving in use to direct said fluid to respective sensing means.
- 6. A device for measuring the concentration of an analyte in a fluid, comprising a support member, analyte sensing means provided thereon for measuring said concentration and a microchannel in fluid communication with said analyte sensing means for conveying said fluid to said sensing means.
- 9. A device for measuring the concentration of an analyte in a fluid, comprising a support member and a microchannel provided on said support member for conveying said fluid across the support member, wherein one or more reagents for reacting with said analyte is coated on a wall of the microchannel.
- 12. A device for measuring the concentration of an analyte in a fluid, comprising a support member, means provided on the support member for sensing said analyte, wherein said support member further comprises fluid extraction means arranged to direct fluid to said analyte sensing means via a conduit on the support member.
- 17. A device for measuring the concentration of an analyte in a bodily fluid, comprising skin penetration means, said penetration means being sufficiently short so as to penetrate only the cutaneous layer of skin without penetrating the sub-cutaneous layer, and a support member, said support member comprising an analyte sensing site and a microchannel for conducting said body fluid from said penetration member to said analyte sensing site.
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27. A device for measuring the concentration of a given analyte in a body fluid comprising means for attaching the device to the skin of a subject and a plurality of sensing means for making a plurality of measurements of said concentration over a period of time.
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40. A device for making a plurality of measurements of the concentration of an analyte in a fluid comprising a common sample collection site in fluid communication with the fluid to be measured and a plurality of sensing means for measuring said concentration.
- 42. A device for measuring the concentration of an analyte in a fluid comprising a sensing means for measuring said concentration substantially continuously and calibration sensing means for performing at least one calibration measurement.
- 44. A device as claimed in claim 44 wherein the continuous sensing means and calibration sensing means are provided on a common base member.
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61. An device for administering a substance to a user comprising a measuring device for measuring the concentration of an analyte in a bodily fluid from said user, said measuring device comprising a plurality of analyte sensing means and at least one conduit, preferably a microchannel, for conveying said body fluid to at least one of the sensing means;
- the apparatus further comprising administration means for administering said substance to said user on the basis of said measurement of concentration.
- View Dependent Claims (62, 63, 64, 65, 66)
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71. A device for measuring the concentration of an analyte in a fluid comprising a support member having an open channel on a surface thereof the support member;
- and a second layer laminated onto said support member so as to close said channel.
- View Dependent Claims (72, 73, 74)
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75. A device for obtaining fluid through human or animal skin, comprising a skin penetration member having at least one longitudinal side open, the other sides being arranged so as effectively to cause the penetrated skin to act as the remaining longitudinal side of the member when the penetration member is inserted into the skin.
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77. Apparatus for measuring the light from an assay comprising an elongate conduit portion along which a sample fluid is drawn in use and a light sensitive means arranged to be sensitive to light coming substantially from the longitudinal axis of said conduit portion.
- 78. A disposable skin patch comprising an elongate conduit portion along which a sample fluid is drawn in use and a moulded plastics lens over said conduit portion.
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80. A method of measuring the amount of an analyte in a sample of liquid comprising providing an electrochemical measuring device having a sensor electrode within a microchannel, introducing said sample liquid into said microchannel, and measuring an aggregate current passed by said electrode to give an indication of said amount of analyte in the sample.
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81. An electrochemical device for measuring the amount of an analyte in a sample of liquid comprising a sensor electrode disposed within a microchannel and means for measuring an aggregate current passed by said electrode in use to give an indication of said amount of analyte in the sample.
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82. A method of making a device for measuring the concentration of a substance in a liquid comprising forming a first channel in a substrate material, fitting said channel at least partially with an electrically conductive material, and forming a second channel so as to intersect said first channel, thereby forming two conductive portions on respective opposite sides of the second channel.
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83. A method of fabricating a device for measuring the concentration of an analyte in a fluid comprising providing a support member, forming an open channel on a surface of the support member and laminating a second layer onto said support member so as to close said channel.
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84. An apparatus for obtaining and analyzing a sample of a body fluid from a skin layer, said apparatus comprising:
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a support member;
a channel formed on said support chamber;
said channel having an entrance for receiving said body fluid;
an analyte sensor carried on said support member and positioned to sense an analyte in said fluid within said channel;
a flow controller for influencing a flow of fluid within said channel to said sensor. - View Dependent Claims (85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 105, 121, 122, 123, 124, 157, 158)
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104. A method of continuously sampling and measuring an analyte comprising:
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extracting a fluid into a common collection port;
directing said fluid along a channel towards an analyte sensing means;
performing at least an analyte measurement on the fluid;
switching the flow of fluid from one channel to sequentially at least another channel after a certain period of time; and
performing at least a further analyte measurement.
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106. An apparatus for obtaining and analyzing a sample of a body fluid from a skin layer, said apparatus comprising:
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a support member;
a channel formed on said support chamber by forming channel defining wall on a said support member;
said channel having an entrance for receiving said body fluid;
said channel having a minute size with a volume less than 200 nanoliters;
an analyte sensor carried on said support member and positioned to sense an analyte in said fluid within said channel. - View Dependent Claims (107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 125, 126, 127, 128, 129, 130)
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131. An apparatus for obtaining and analyzing a sample of a body fluid from a skin layer, said apparatus comprising:
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a support member;
a channel formed on said support chamber by forming channel defining wall on a said support member;
said channel having an entrance for receiving said body fluid;
said channel having a reagent deposited on said wall for reacting with an analyte of said fluid when said fluid is within said channel. - View Dependent Claims (132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144)
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145. An apparatus for obtaining and analyzing a sample of a body fluid from a skin layer, said apparatus comprising:
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a support member;
a channel formed on said support chamber by forming channel defining wall on a said support member;
said channel having an entrance for receiving said body fluid;
a fluid extraction member for directing fluid from said skin layer to said entrance;
said channel having a minute size with a volume less than 200 nanoliters;
an analyte sensor carried on said support member and positioned to sense an analyte in said fluid within said channel. - View Dependent Claims (146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156)
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159. An apparatus for obtaining and analyzing a sample of a body fluid from a skin layer, said apparatus comprising:
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a support member;
a plurality of channels each formed on said support chamber by forming channel defining walls on a said support member;
each of said channels having an entrance for receiving said body fluid;
a plurality of analyte sensors each associated with a respective one of said plurality of channels, each of said analyte sensors carried on said support member and positioned to sense an analyte in said fluid within said respective one of said plurality of channels. - View Dependent Claims (160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172)
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173. A method of making a device for measuring the concentration of a substance in a liquid, said method comprising:
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forming a first channel in a substrate material;
fitting said channel at least partially with an electrically conductive material;
forming a second channel so as to intersect with said first channel.
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174. A method of fabricating a device for measuring the concentration of an analyte in a fluid, said method comprising:
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forming a support member;
forming an open channel on a surface of the support member;
laminating a layer onto said support member so as to close said channel. - View Dependent Claims (175, 176)
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Specification