Device and method for assessing asthma and other diseases
First Claim
1. A method for assessing a disease in a subject, said method comprising:
- collecting condensate from a subject'"'"'s breath, said condensate having an acetic acid or acetate concentration or both an acetic acid and acetate concentration;
testing said condensate to determine said acetic acid or acetate concentration or both said acetic acid and acetate concentrations; and
evaluating said acetic acid or acetate concentration or both said acetic acid and acetate concentrations to determine the presence, absence or status of a disease in the subject.
2 Assignments
0 Petitions
Accused Products
Abstract
Device and method for non-invasively monitoring asthma and other respiratory diseases, as well as non-respiratory diseases. The method includes collecting condensate from a subject'"'"'s breath, testing the condensate to determine its acetic acid/acetate level or concentration, and evaluating these properties to determine the presence, absence or status of a respiratory or non-respiratory disease in the subject. The method may also include, prior to the testing step, standardizing the volatile substances that may be present within the condensate in a degassing or gas standardizing step. The device includes a mouthpiece apparatus configured to receive breath from a subject, a condensation apparatus to condense the subject'"'"'s breath and produce a condensate, and a collection apparatus having a collection chamber containing means for testing the condensate to determine the acetic acid and/or acetate concentration. The device may also include a system for removing or standardizing the volatile substances that may be present with the condensate. The device and method may be utilized without condensing a subject'"'"'s breath and collecting the same.
44 Citations
71 Claims
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1. A method for assessing a disease in a subject, said method comprising:
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collecting condensate from a subject'"'"'s breath, said condensate having an acetic acid or acetate concentration or both an acetic acid and acetate concentration;
testing said condensate to determine said acetic acid or acetate concentration or both said acetic acid and acetate concentrations; and
evaluating said acetic acid or acetate concentration or both said acetic acid and acetate concentrations to determine the presence, absence or status of a disease in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for assessing asthma in a subject, comprising:
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providing a device comprising a mouthpiece apparatus, a condensation apparatus and a collection apparatus;
receiving a subject'"'"'s breath in said mouthpiece apparatus;
condensing said breath in said condensation apparatus to form a condensate;
collecting said condensate in said collection apparatus;
testing said condensate within said collection apparatus to determine acetic acid or acetate concentration or both said acetic acid and acetate concentrations; and
evaluating said acetic acid or acetate concentration or both said acetic acid and acetate concentrations to determine the presence, absence or status of asthma in the subject.
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33. A method for assessing asthma in a subject, comprising:
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providing a device comprising a mouthpiece apparatus and a condensation apparatus;
receiving a subject'"'"'s breath in said mouthpiece apparatus;
condensing said breath in said condensation apparatus to form a condensate;
collecting said condensate in said condensing apparatus;
testing said condensate within said condensation apparatus to determine acetic acid or acetate concentration or both said acetic acid and acetate concentrations; and
evaluating said acetic acid or acetate concentration or both said acetic acid and acetate concentrations to determine the presence, absence or status of asthma in the subject.
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34. A device for assessing a disease in a subject, said device comprising:
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a mouthpiece apparatus configured to receive breath from a subject;
a condensation apparatus configured for operative connection to said mouthpiece apparatus, and being further configured to condense the subject'"'"' breath and produce a condensate having acetic acid or acetate or both said acetic acid and acetate; and
a collection apparatus configured for operative connection to said condensation apparatus, said collection apparatus comprising a collection chamber containing means for testing said condensate to determine said acetic acid or acetate concentration or both said acetic acid and acetate concentrations, wherein the subject'"'"'s breath may be received, condensed and evaluated in a single device to determine the presence, absence or status of a disease in the subject. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A device for assessing a disease in a subject, said device comprising:
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a mouthpiece apparatus configured to receive breath from a subject;
a condensation apparatus configured for operative connection to said mouthpiece apparatus, and being further configured to condense and collect the subject breath and produce a condensate having acetic acid or acetate concentration or both said acetic acid and acetate concentrations; and
said condensation apparatus comprising a means for testing said condensate to determine said acetic acid or acetate concentration or both said acetic acid and acetate concentrations. - View Dependent Claims (59, 60, 61)
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62. A method for assessing a disease in a subject, said method comprising:
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said subject exhaling through a measuring device or substance, said measuring device or substance effective for detecting acetic acid or acetate or both acetic acid and acetate;
testing said detected acetic acid or acetate or both said detected acetic acid and acetate to determine said acetic acid or acetate concentration or both said acetic acid or acetate concentrations; and
evaluating said acetic acid or acetate concentration or both said acetic acid and acetate concentrations to determine the presence, absence or status of a disease in the subject. - View Dependent Claims (63, 64, 65, 66, 67, 68)
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69. A device for assessing a disease in a subject, said device comprising:
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a mouthpiece apparatus configured to receive breath from a subject;
a measuring device or substance configured for operative connection to said mouthpiece apparatus, said measuring device or substance effective for detecting acetic acid or acetate concentration or both said acetic acid and acetate concentrations from said subject'"'"'s breath;
a means for testing said trapped acetic acid and acetate to determine said acetic acid or acetate concentration or both said acetic acid and acetate concentrations; and
an evaluating means for evaluating said acetic acid or acetate concentration or both said acetic acid and acetate concentrations to determine the presence, absence or status of a disease in the subject. - View Dependent Claims (70, 71)
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Specification