Specimen analyzing implement

• US 20040137640A1
• Filed: 10/03/2003
• Published: 07/15/2004
• Est. Priority Date: 04/12/2001
• Status: Active Grant

• Current Assignee: ARKRAY, Inc
• Original Assignee: ARKRAY, Inc
• Inventors: Hirao, Konomu, Murata, Yasuhito
• Granted Patent: US 7,867,756 B2
• Time in Patent Office: Days
• US Class Current: 436/514
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: B01L 3/505 flexible containers not provided for above
• CPC Class Codes: G01N 33/558 using diffusion or migration of antigen or antibody immunochromatographic test strips G01N33/54387
• CPC Class Codes: Y10S 436/807 Apparatus included in process claim, e.g. physical support structures
• CPC Class Codes: Y10S 436/81 Tube, bottle, or dipstick

Abstract

A sample analysis device is provided in which a target component to be analyzed is prevented from being contaminated by a sample itself, which can be formed in an appropriate size, and which has excellent operability. In a sample analysis device 1 in which a sample is to be held in a porous sheet 13, supporting films 11 and 12 are stuck on front and rear faces of the porous sheet 13, respectively, and a sample supply hole 14 is formed in a part of the supporting films.

Claims

1. A sample analysis device comprising a porous sheet in which a sample is to be held, the sample analysis device further comprising:

a supporting film arranged on a front face of the porous sheet.

2. The sample analysis device according to claim 1, wherein

the supporting film is stuck on the front face of the porous sheet, and

a sample supply hole is formed in a part of the supporting film.

3. The sample analysis device according to claim 2, further comprising:

another supporting film stuck on a rear face of the porous sheet.

4. The sample analysis device according to any one of claims 1 to 3, wherein a part of a side face of the porous sheet is exposed to outside.

5. The sample analysis device according to any one of claims 1 to 4, wherein air vent holes are formed in a part of the supporting film.

6. The sample analysis device according to any one of claims 1 to 5, further comprising:

a protective film that is to be stuck on a surface of the supporting film having the sample supply hole after the sample is supplied.

7. The sample analysis device according to any one of claims 1 to 6, wherein the porous sheet is an asymmetric porous sheet in which diameters of pores vary in a thickness direction of the sheet.

8. The sample analysis device according to claim 7, wherein the asymmetric porous sheet has a groove parallel with a width direction of the sheet.

9. The sample analysis device according to claim 1, further comprising:

a base film,

wherein

a through hole is formed in a part of the supporting film so as to constitute a sample supply hole,

the supporting film functions as a cover film, and

the porous sheet is caught directly or indirectly by the cover film and the base film so that the porous sheet, the cover film, and the base film are integrally provided.

10. The sample analysis device according to claim 9, wherein

the porous sheet is arranged on the base film, and

the base film and the cover film are bonded with each other at ends thereof in a lengthwise direction using a bonding member.

11. The sample analysis device according to claim 9, wherein

a pair of the base films are provided, which partially are bonded with ends of the cover film in a lengthwise direction thereof via bonding members, respectively, and each of which has a protrusion that protrudes toward center in the lengthwise direction from the bonding member, and

ends of the porous sheet in the lengthwise direction are arranged on the projections, respectively.

12. The sample analysis device according to any one of claims 9 to 11, wherein the porous sheet has a lining layer on its bottom face.

13. The sample analysis device according to any one of claims 9 to 12, further comprising:

at least one of a separating layer and a sample holding layer, arranged between the cover film and the porous sheet at a position corresponding to the sample supply hole, the separating layer being for separating and removing unnecessary matters in the sample, and the sample holding layer being for temporarily holding the sample.

14. The sample analysis device according to claim 13, wherein the separating layer is bonded with the cover film using a bonding member.

15. The sample analysis device according to any one of claims 9 to 14, wherein the cover film further includes a through hole that constitutes a spreading solvent supply hole on an upstream side with respect to the sample supply hole in a direction in which the sample is spread in the porous sheet.

16. The sample analysis device according to claim 15, further comprising:

a spreading solvent holding layer for holding a spreading solvent and supplying the same to the porous sheet, the spreading solvent holding layer being arranged between the cover film and the porous sheet at a position corresponding to the spreading solvent supply hole.

17. The sample analysis device according to claim 16, wherein the spreading solvent holding layer is bonded on a cover film using a bonding member.

18. The sample analysis device according to any one of claims 9 to 17, further comprising:

an absorbing layer arranged between the cover film- and the porous sheet at an end on a downstream side in a direction in which the sample is spread in the porous sheet.

19. The sample analysis device according to claim 18, wherein the absorbing layer is bonded with the cover film using a bonding member.

20. The sample analysis device according to any one of claims 9 to 19, wherein at least one of the cover film and the base film includes a detection part on a downstream side with respect to the sample supply hole in a direction in which the sample is spread in the porous sheet.

21. The sample analysis device according to claim 20, wherein the detection part in the at least one of the cover film and the base film is optically transparent.

22. The sample analysis device according to claim 20, wherein the detection part is a through hole provided in the at least one of the cover film and the base film.

23. The sample analysis device according to any one of claims 9 to 22, wherein the porous sheet includes a reagent part containing a reagent on a downstream side with respect to the sample supply hole in a direction in which the sample is spread in the porous sheet.

24. The sample analysis device according to any one of claims 20 to 23, wherein the porous sheet includes a reagent part containing a reagent between the sample supply hole and the detection part in a direction in which the sample is spread in the porous sheet.

25. The sample analysis device according to claim 20 or 21, wherein at least a part of the lining layer corresponding to the detection part is optically transparent.

26. The sample analysis device according to any one of claims 10 to 25, wherein the bonding member is a double-faced tape.

27. The sample analysis device according to any one of claims 1 to 26, wherein

the porous sheet includes a sample-spotted part at which the sample is to be spotted, and one or more reagent parts containing one or more reagents, and

the reagent parts are arranged around the sample-spotted part so that when the sample is spotted on the sample-spotted part, the sample is spread radially and reaches the reagent parts.