Signal detection techniques for the detection of analytes
First Claim
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1. A method of detecting target analytes in a sample comprising:
- a) providing an array comprising a plurality of electrodes, at least one of which comprises an assay complex comprising;
i) a capture binding ligand covalently attached to said electrode;
ii) a target analyte; and
iii) an electron transfer moiety;
b) applying a first input signal to said assay complex;
c) receiving an output signal;
d) processing said output signal to detect the presence of said target analytes.
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Abstract
The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
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10 Claims
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1. A method of detecting target analytes in a sample comprising:
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a) providing an array comprising a plurality of electrodes, at least one of which comprises an assay complex comprising;
i) a capture binding ligand covalently attached to said electrode;
ii) a target analyte; and
iii) an electron transfer moiety;
b) applying a first input signal to said assay complex;
c) receiving an output signal;
d) processing said output signal to detect the presence of said target analytes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of detecting target analytes in a sample comprising:
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a) providing an array comprising a plurality of electrodes, at least one of which comprises an assay complex comprising;
i) a capture binding ligand covalently attached to said electrode;
ii) a target analyte; and
iii) an electron transfer moiety;
b) applying a first input signal to said assay complex, wherein said input signal comprises the sum of multiple frequencies at a plurality of amplitudes;
c) receiving an output signal;
d) processing said output signal to detect the presence of said target analytes.
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Specification