Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route
First Claim
1. A composition for delivery of sumatriptan consisting of a condensation aerosol a) formed by volatilizing a thin layer of sumatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of sumatriptan and condensing the heated vapor of sumatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% sumatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing sumatriptan, frovatriptan, or naratriptan that are used in inhalation therapy. In a method aspect of the present invention, sumatriptan, frovatriptan, or naratriptan is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of sumatriptan, frovatriptan, or naratriptan on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering sumatriptan, frovatriptan, or naratriptan through an inhalation route is provided which comprises: a) a thin coating of a sumatriptan, frovatriptan, or naratriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol
36 Citations
18 Claims
-
1. A composition for delivery of sumatriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of sumatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of sumatriptan and condensing the heated vapor of sumatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% sumatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
-
4. A composition for delivery of frovatriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of frovatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of frovatriptan and condensing the heated vapor of frovatriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% frovatriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
-
7. A composition for delivery of naratriptan consisting of a condensation aerosol
a) formed by volatilizing a thin layer of naratriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of naratriptan and condensing the heated vapor of naratriptan to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% naratriptan degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
-
10. A method of producing sumatriptan in an aerosol form comprising:
-
a. heating a thin layer of sumatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the sumatriptan to form a heated vapor of the sumatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the sumatriptan comprising less than 5% sumatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (11, 12)
-
-
13. A method of producing frovatriptan in an aerosol form comprising:
-
a. heating a thin layer of frovatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the frovatriptan to form a heated vapor of the frovatriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the frovatriptan comprising less than 5% frovatriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (14, 15)
-
-
16. A method of producing naratriptan in an aerosol form comprising:
-
a. heating a thin layer of naratriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the naratriptan to form a heated vapor of the naratriptan, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the naratriptan comprising less than 5% naratriptan degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (17, 18)
-
Specification