PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASE
First Claim
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1. A pharmaceutical composition comprising an immunogenic Aβ
- fragment linked to an immunoglobulin carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances an immune response comprising antibodies to the Aβ
fragment.
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer'"'"'s disease. In such methods, a suitable agent is Aβ peptide or an antibody thereto.
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29 Claims
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1. A pharmaceutical composition comprising an immunogenic Aβ
- fragment linked to an immunoglobulin carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances an immune response comprising antibodies to the Aβ
fragment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
- fragment linked to an immunoglobulin carrier molecule to form a conjugate and an adjuvant, wherein the adjuvant enhances an immune response comprising antibodies to the Aβ
Specification