Pharmaceutical compositions comprising modified cns-derived peptides for promoting nerve regeneration and prevention of nerve degeneration

  • US 20040192588A1
  • Filed: 01/05/2004
  • Published: 09/30/2004
  • Est. Priority Date: 01/14/2001
  • Status: Abandoned Application
First Claim
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1. A composition for promoting nerve regeneration or reducing or inhibiting degeneration in the central nervous system or peripheral nervous system to ameliorate the effects of injury or disease, comprising a pharmaceutically acceptable carrier and an active ingredient selected from:

  • (a) a peptide obtained by modification of a self-peptide derived from a CNS-specific antigen, which modification consists in the replacement of one or more amino acid residues of the self-peptide by different amino acid residues, said modified CNS peptide still being capable of recognizing the T-cell receptor recognized by the self-peptide but with less affinity (hereinafter “

    modified CNS peptide”

    );

    (b) a nucleotide sequence encoding a modified CNS peptide of (a);

    (c) T cells activated by a modified CNS peptide of (a); and

    (d) any combination of (a)-(c).

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