Bronchoscopic lung volume reduction method
First Claim
1. A method of minimally invasively performing lung volume reduction to treat a diseased lung section, the method comprising:
- deflating one or more cavities of at least a portion of the diseased lung section to bring opposing walls surrounding each of one or more of said cavities substantially closer together to provide a substantially reduced cavity;
allowing a substantial portion of the opposing walls of said one or more cavities to adhere; and
placing a device within an airway of the lung upstream from said one or more cavities, the device configured to substantially preclude inspiration downstream of said device to prevent substantial re-inflation of said one or more cavities.
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Accused Products
Abstract
A method of minimally invasively reducing a volume of a hyper-inflated target section of diseased lung comprising the steps of introducing a bronchoscope into a patient'"'"'s airway to a position adjacent the target section and equilibrating air within the target section with atmospheric air to at least partially deflate the target lung section; injecting an inflammation-causing substance into the target section to precipitate adhesion of the walls within the target lung section, preventing substantial re-inflation of the target section by occluding an airway upstream of the target section for a period of time, and removing the airway occlusion after the target section has substantially permanently been reduced in volume. The injected substance can be autologous blood or a constituent thereof.
215 Citations
30 Claims
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1. A method of minimally invasively performing lung volume reduction to treat a diseased lung section, the method comprising:
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deflating one or more cavities of at least a portion of the diseased lung section to bring opposing walls surrounding each of one or more of said cavities substantially closer together to provide a substantially reduced cavity;
allowing a substantial portion of the opposing walls of said one or more cavities to adhere; and
placing a device within an airway of the lung upstream from said one or more cavities, the device configured to substantially preclude inspiration downstream of said device to prevent substantial re-inflation of said one or more cavities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A minimally invasive method of reducing the volume of a cavity in a lung, the method comprising:
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inserting a catheter into the lung via the patient'"'"'s trachea;
removing at least some of the air in the cavity;
injecting an inflammation-causing substance within the cavity so that at least a portion of the walls surrounding said cavity become coated with the substance; and
placing an occlusion device in an airway upstream of said cavity. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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24. A method of reducing a volume of a diseased lung section, comprising:
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guiding a distal end of a bronchoscope through a patient'"'"'s airway to the diseased lung section;
employing the bronchoscope to inject an inflammation-causing substance into the diseased lung section;
temporarily deploying an occlusion device in an airway proximal to the diseased lung section. - View Dependent Claims (25, 26, 27)
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28. A minimally invasive method of reducing a volume of an enlarged target region of a lung comprising:
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guiding a distal end of an bronchoscope to a position adjacent the target region;
placing a catheter lumen in fluid communication with an interior of the target region;
equilibrating the target region with atmospheric air by opening the lumen to fluid communication with a volume of air at atmospheric pressure;
deploying one or more occlusion devices in one or more airways leading into the target region, thereby substantially isolating the target region from air flow in at least an inspiratory direction; and
injecting an inflammation-causing substance.
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29. A minimally invasive method of reducing a volume of an enlarged target region of a lung comprising:
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guiding a distal end of an bronchoscope to a position adjacent the target region;
placing a catheter lumen in fluid communication with an interior of the target region;
equilibrating the target region with atmospheric air by opening the lumen to fluid communication with a volume of air at atmospheric pressure;
deploying one or more occlusion devices in one or more airways leading into the target region, thereby substantially isolating the target region from air flow in at least an inspiratory direction.
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30. A minimally invasive method of reducing a volume of an enlarged target region of a lung comprising:
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guiding a distal end of an bronchoscope to a position adjacent the target region;
placing a catheter lumen in fluid communication with an interior of the target region;
equilibrating the target region with atmospheric air by opening the lumen to fluid communication with a volume of air at atmospheric pressure; and
injecting an inflammation-causing substance.
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Specification