Microfluidic devices and methods
First Claim
Patent Images
1. A microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the microfluidic device comprising:
- a microfluidic body having first and second major surfaces and at least one edge surface;
at least one microchannel disposed between the first and second major surfaces, the microchannel having a microfabricated surface; and
at least one outlet in fluid communication with the microchannel and disposed along the edge surface, the outlet recessed into the microfluidic body relative to an adjacent portion of the edge surface.
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Abstract
Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include first and second surfaces, at least one microchannel formed by the surfaces, and an outlet at an edge of the surfaces which is recessed back from an adjacent portion of the edge. Hydrophilic surfaces and/or hydrophobic surfaces guide substances out of the outlet. A source of electrical potential can help move substances through the microchannel, separate substances and/or provide electrospray ionization.
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Citations
173 Claims
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1. A microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the microfluidic device comprising:
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a microfluidic body having first and second major surfaces and at least one edge surface;
at least one microchannel disposed between the first and second major surfaces, the microchannel having a microfabricated surface; and
at least one outlet in fluid communication with the microchannel and disposed along the edge surface, the outlet recessed into the microfluidic body relative to an adjacent portion of the edge surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 50)
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40. A microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the microfluidic device comprising:
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a microfluidic body having first and second major surfaces and at least one edge surface;
at least one microchannel disposed between the first and second major surfaces, the microchannel having a microfabricated surface;
at least one outlet in fluid communication with the microchannel and disposed along the edge surface, the outlet recessed into the microfluidic body relative to an adjacent portion of the edge surface; and
at least one protruding tip separated from the outlet and disposed in a path of fluid flow from the outlet, the protruding tip recessed into the microfluidic body relative to the adjacent portion of the edge surface. - View Dependent Claims (41, 42, 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the microfluidic device comprising:
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a substrate comprising at least one layer, the substrate including at least one protruding tip and at least one microchannel, wherein the substances are movable within the microchannel;
a cover arranged over the substrate, the cover comprising a bottom surface at least partially contacting the substrate and a top surface; and
at least one outlet in fluid communication with the microchannel for allowing egress of the substances from the microchannel. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95)
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96. A microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the microfluidic device comprising:
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a microfluidic body having first and second major surfaces and at least one edge surface;
at least one microchannel disposed between the first and second major surfaces, the microchannel having a microfabricated surface; and
a layer of film disposed between the first and second major surfaces to form at least one tip, the tip in fluid communication with the microchannel and recessed into the microfluidic body relative to an adjacent portion of the edge surface. - View Dependent Claims (97, 98, 99, 100, 101, 102)
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103. A method of making a microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the method comprising:
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fabricating a substrate comprising;
at least one microchannel having a microfabricated surface; and
an outlet in fluid communication with the microchannel and disposed along an edge surface of the substrate, the outlet recessed into the substrate relative to an adjacent portion of the edge surface; and
applying a cover to the substrate. - View Dependent Claims (104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145)
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146. A method for making a microfluidic device for providing one or more substances to a mass spectrometer for analysis of the substances, the method comprising:
fabricating a microfluidic body comprising;
first and second major surfaces with an edge surface therebetween;
at least one microchannel disposed between the first and second major surfaces, the microchannel having a microfabricated surface; and
an outlet in fluid communication with the microchannel and disposed along the edge surface, the outlet recessed into the microfluidic body relative to an adjacent portion of the edge surface. - View Dependent Claims (147, 148, 149, 150)
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151. A method for providing at least one substance from a microfluidic device into a mass spectrometer, the method comprising:
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moving the at least one substance through at least one microchannel in the microfluidic device; and
causing the at least one substance to pass from the microchannel out of an outlet at a recessed edge of the microfluidic device. - View Dependent Claims (152, 153, 154, 155, 156, 157, 158, 159, 160, 161)
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162. A method of making microfluidic devices for providing one or more substances to a mass spectrometer for analysis of the substances, the method comprising:
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forming at least one microchannel on a first substrate;
forming a recessed edge on the first substrate and a second substrate;
providing a layer of film having at least one tip and at least one alignment feature;
aligning the layer of film between the first and second substrates; and
bonding the layer of film between the first and second substrates. - View Dependent Claims (163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173)
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Specification