Medical device with therapeutic agents

• US 20040210208A1
• Filed: 04/16/2003
• Published: 10/21/2004
• Est. Priority Date: 04/16/2003
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Paul, Ram H., Sirota, Daniel J., Amarant, Paul D.
• Granted Patent: US 7,306,580 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0017 specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections

Abstract

A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.

Claims

1. A medical device for at least partial implantation, comprising:

a main body having a first end, a second end, and a length extending from the first end to the second end;

a first section along the length having a first therapeutic agent; and

a second section along the length having a second therapeutic agent.

2. The medical device of claim 1, wherein the main body comprises a cannula having an interior surface, an exterior surface, and defining a lumen.

3. The medical device of claim 1, wherein the first therapeutic agent comprises an antiproliferative.

4. The medical device of claim 3, wherein the antiproliferative comprises paclitaxel.

5. The medical device of claim 3, wherein the second therapeutic agent comprises an antimicrobial.

6. The medical device of claim 5, wherein the antimicrobial is a member selected from the group consisting of antibiotics, antiseptics, and disinfectants.

7. The medical device of claim 6, wherein the antimicrobial is an antibiotic.

8. The medical device of claim 7, wherein the antibiotic is one or more members selected from the group consisting of tetracyclines, rifamycins, macrolides, penicillins, cephalosporins, other beta-lactam antibiotics, aminoglycosides, chloramphenicol, sufonamides, glycopeptides, quinolones, fusidic acid, trimethoprim, metronidazole, clindamycin, mupirocin, polyenes, azoles and beta-lactam inhibitors.

9. The medical device of claim 7, wherein the antibiotic comprises a combination of rifampin and minocycline.

10. The medical device of claim 1, wherein the medical device has an exterior surface, the first therapeutic agent is impregnated within the first section, and the second therapeutic agent is posited on the exterior surface of the second section.

11. The medical device of claim 1, further comprising a separator spacing the first section from the second section.

12. The medical device of claim 11, wherein the separator comprises a portion of the main body having a reduced diameter.

13. The medical device of claim 11, wherein the marker separator comprises a band surrounding the main body.

14. The medical device of claim 11, wherein the marker separator comprises a dye disposed in or on the main body.

15. A medical device for at least partial implantation comprising:

a cannula having first and second ends, interior and exterior surfaces, and defining a lumen;

a first section proximal the first end having a first therapeutic agent; and

a second section proximal the second end having a second therapeutic agent.

16. The medical device of claim 15, wherein the first therapeutic agent is impregnated within the first section, and the second therapeutic agent is posited on one of the interior and exterior surfaces of the second section.

17. The medical device of claim 15, wherein the first therapeutic agent is impregnated within the first section, and the second therapeutic agent is posited on the interior surface and the exterior surface of the second section.

18. A cannula for at least partial implantation, comprising:

a main body having first and second ends, interior and exterior surfaces, and defining a lumen;

a first section proximal the first end;

a second section proximal the second end;

an antiproliferative impregnated within the first section; and

an antimicrobial coated on the interior and exterior surfaces of the second section.

19. (cancelled pursuant to restriction requirement)

20. A method of establishing access to a vessel of a body, comprising:

providing a medical device comprising a cannula having a distal end, a proximal end, an interior surface, an exterior surface, and defining a lumen, the cannula further having a length extending from the proximal end to the distal end, a first section with a first therapeutic agent extending along part of the length, and a second section with a second therapeutic agent extending along part of the length,

implanting the distal end into the body; and

forming an interface between the distal end and the vessel.

21. The medical device of claim 20, wherein the implanting the distal end comprises positioning the first section below a subcutaneous layer of the body.

22. The medical device of claim 21, wherein the implanting the distal end further comprises positioning the second section across a subcutaneous layer of the body.

23. The medical device of claim 21, wherein the implanting the distal end further comprises positioning the second section within a subcutaneous layer of the body.

24. A medical device for at least partial implantation, comprising:

a main body having a first end, a second end, and a length extending from the first end to the second end;

a first section along the length having a first therapeutic agent comprising one or more members selected from the group consisting of antiproliferatives, anticoagulants, antithrombotics, thrombolytics, and fibrinolytics; and

a second section along the length having a second therapeutic agent.