Aseptic system and method for using the same

• US 20040215362A1
• Filed: 04/06/2004
• Published: 10/28/2004
• Est. Priority Date: 04/25/2003
• Status: Abandoned Application

• Current Assignee: Shibuya Kogyo Company Limited
• Original Assignee: Shibuya Kogyo Company Limited
• Inventors: Ueda, Hiroshi, Kokubo, Mamoru
• Application Number:
  US10/819,252
• Publication Number:
  US 20040215362A1
• Time in Patent Office: Days
• US Class Current: 700/130
• CPC Class Codes: A61L 2/04 Heat A61L2/08 takes precedence
• CPC Class Codes: A61L 2/208 Hydrogen peroxide
• CPC Class Codes: A61L 2202/122 Chambers for sterilisation
• CPC Class Codes: C12M 37/00 Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination C12M23/38 takes precedence; filtration in general and filters per se B01D24/00-B01D41/00; autoclaves B01J3/04; treatment of microorganisms with electrical or wave energy C12N13/00
• CPC Class Codes: C12M 41/14 Incubators; Climatic chambers per se B01L1/00

Abstract

The isolator 2 of incubate equipment 1 has six side walls and are connected to an incubator 3, a refrigerator 4, surface sterilizing means 5, heating and sterilizing means 6, and RTP 7 through opening-and-closing doors 3A, 4A, 5A, 6A, and 7A, and there is provided in the isolator 2 a half suit 8 and a centrifugal separator 9 which separates the body fluid of a human body or an animal into supernatant liquid and precipitation liquid.

And when incubating of the cells is performed normally, the surface of the incubation container is sterilized by this surface sterilizing means and then carried out to the exterior of the incubate equipment and when there are abnormalities in the incubate of the cells, the incubation container is heated and sterilized by the heating and sterilizing means thereby the whole cells in the incubation container are sterilized and then carried out to the exterior of the incubate equipment.

The system has high scalability and operation efficiency and any microorganisms adhered to the surface of an object to be sterilized or an incubation container can be prevented from flowing into the exterior of the isolator.

Claims

1. An aseptic system comprising an isolator which is isolated from the external atmosphere and maintained in an aseptic condition in the inside, wherein the isolator is formed in a polygonal shape with five or more side walls at least four of which have communicating openings to the outside and each of the communicating openings is provided with an opening-and-closing door respectively.

3. The aseptic system according to claim 1, wherein there is provided at least either one of a half suit, a glove and a robot in the isolator and the operational range of the half suit, glove and robot reaches the range beyond the above-mentioned communicating opening.

4. The aseptic system according to claim 1, wherein the above-mentioned isolator is provided with an incubator through a communicating opening and communicating openings are provided with opening-and-closing doors each of which opens and closes the communicating opening and the incubating of the cells are conducted in the aseptic system.

5. The aseptic system according to claim 1, wherein the isolator is provided with a centrifugal separator and a body fluid obtained from human body or animal is centrifuged therewith.

2. An aseptic system comprising an isolator which is isolated from the external atmosphere and maintained in an aseptic condition in the inside, surface sterilizing means to sterilize the surface of an object to be sterilized and heating and sterilizing means to heat and sterilize an object to be sterilized, wherein at least two of the isolator side walls have communicating openings to the surface sterilizing means and to the heating and sterilizing means and each of the communicating openings is provided with opening-and-closing doors respectively for opening and closing the communicating openings.

6. A method for using an aseptic system comprising an isolator which is isolated from the external atmosphere and maintained in an aseptic condition in the inside and surface sterilizing means to sterilize the surface of an incubation container and heating and sterilizing means to heat and sterilize an incubation container, wherein when the incubation container is taken out to the exterior from the isolator, in the case that the incubating in the incubation container has proceeded normal, the surface of the incubation container is sterilized by the surface sterilizing means, and in the case that the incubating in the incubation container has not proceeded normal, the incubation container is heated and sterilized by the heating and sterilizing means.