Process for forming a porous drug delivery layer
First Claim
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1. A process for forming a drug delivery device comprising:
- providing a substrate; and
electroplating onto said substrate a porous layer having openings connected to pores of a controlled size and nature.
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Abstract
The present invention is directed to a process for forming a drug delivery device by electroplating onto a substrate a porous layer having pores of a controlled size and density and loading a drug into the pores. Preferably the drug delivery device is a gold stent plated with a gold porous layer.
79 Citations
26 Claims
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1. A process for forming a drug delivery device comprising:
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providing a substrate; and
electroplating onto said substrate a porous layer having openings connected to pores of a controlled size and nature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A process for forming a drug delivery stent comprising:
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providing a mandrel;
coating said mandrel with a resist;
exposing portions of said resist to a light pattern so as to form a stent pattern on said mandrel in said resist;
electroplating a stent having a percent porosity less than 1% on said mandrel;
electroplating a porous layer having openings connected to pores of a controlled size and nature on said stent; and
removing said resist and said mandrel. - View Dependent Claims (19)
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20. A process for forming a drug delivery stent comprising:
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providing a prefabricated stent; and
electroplating a porous layer having openings connected to pores of a controlled size and nature on said stent. - View Dependent Claims (21, 22)
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23. A process for forming a drug delivery device comprising:
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providing a substrate;
electroplating onto said substrate a porous layer having pores of a controlled size and nature, wherein said porous layer has a percent porosity greater than about 1%; and
loading a drug into said pores. - View Dependent Claims (24)
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25. A process for forming an implantable drug delivery device, comprising:
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providing a sacrificial mandrel;
electroplating a porous layer on said mandrel to produce a vessel on said mandrel;
creating at least one hole in said vessel to expose a portion of said mandrel;
dissolving said mandrel;
loading said vessel with one or more drugs; and
sealing any of said holes. - View Dependent Claims (26)
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Specification