Targeted release

  • US 20040259768A1
  • Filed: 08/30/2003
  • Published: 12/23/2004
  • Est. Priority Date: 09/03/2002
  • Status: Active Grant
First Claim
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1. An inhibitor which is deactivatable by a reagent produced by a target cell comprising:

  • (a) a first moiety that binds, inhibits, suppresses, neutralizes, or decreases activity of a biologically active agent wherein said first moiety is operably linked to;

    (b) a second moiety specifically cleavable by a reagent produced by a target cell, wherein said first and second moieties are not attached in nature and wherein specific cleavage of said second moiety causes reduction of binding, inhibiting, suppressing, or neutralizing activity of said inhibitor.

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