Intron associated with myotonic dystrophy type 2 and methods of use

• US 20050003426A1
• Filed: 07/14/2004
• Published: 01/06/2005
• Est. Priority Date: 05/11/2001
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Liquori, Christina, Day, John W., Ranum, Laura P.W.
• Granted Patent: US 7,442,782 B2
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: C07K 14/4703 Inhibitors; Suppressors
• CPC Class Codes: C07K 14/471 Myotonic dystrophy
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers

Abstract

The present invention provides methods for identifying individuals not at risk for developing myotonic dystrophy type 2 (DM2), and individuals that have or at risk for developing DM2. The present invention also provides isolated polynucleotides that include a repeat tract within intron 1 of the zinc finger protein 9.

Claims

1-16. -16. Canceled.

17. An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of about nucleotides 1-14468 of SEQ ID NO:

1, about nucleotides 14474-22400 of SEQ ID NO;

1, and the complements thereof.

18. An isolated polynucleotide comprising about nucleotides 17501-17701 of SEQ ID NO:

1, and the complements thereof.

19. An isolated polynucleotide comprising about nucleotides 17501-17701 of SEQ ID NO:

1 and a repeat tract, and the complements thereof.

20. An isolated polynucleotide comprising about nucleotides 17858-18062 of SEQ ID NO:

1, and the complements thereof.

21. An isolated polynucleotide comprising about nucleotides 17858-18062 of SEQ ID NO:

1 and a repeat tract, and the complements thereof.

22. An isolated polynucleotide comprising at least about 15 consecutive nucleotides from nucleotides 16701-17701 of SEQ ID NO:

1.

23. An isolated polynucleotide comprising at least about 15 consecutive nucleotides from nucleotides 17858-18862 of SEQ ID NO:

1.