Test strip with slot vent opening
First Claim
1. A test strip, comprising:
- a base substrate having a reagent layer disposed thereon;
a covering layer overlying the base substrate and comprising a chamber cover and a body cover having a slot therebetween, the slot being positioned over the reagent layer; and
a sample receiving chamber disposed between the base substrate and the covering layer, the slot being in communication with the sample receiving chamber and defining a vent opening in the covering layer that allows air to escape as fluid enters the sample receiving chamber.
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0 Petitions
Accused Products
Abstract
A test strip with a covering layer having a novel slot. The slot divides the inventive covering layer into two parts and provides a vent opening that allows air to escape as fluid enters a cavity or sample receiving chamber formed in the test strip. In preferred embodiments, the covering layer is clear such that the user can see through it and the slot doubles as a “fill line.” The user can thus watch the fluid sample enter the test strip, progress through the capillary cavity, and then stop at the slot or fill-line. This provides positive assurance to the user that the sample size is sufficient and the test strip has been filled properly. The present invention also provides an advantageous method of mass-producing the inventive test strips without having to align the slot or vent opening laterally with respect to the test strips and without having to punch a vent opening. The method is also well suited to mass production by roll processing techniques.
376 Citations
131 Claims
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1. A test strip, comprising:
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a base substrate having a reagent layer disposed thereon;
a covering layer overlying the base substrate and comprising a chamber cover and a body cover having a slot therebetween, the slot being positioned over the reagent layer; and
a sample receiving chamber disposed between the base substrate and the covering layer, the slot being in communication with the sample receiving chamber and defining a vent opening in the covering layer that allows air to escape as fluid enters the sample receiving chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A test strip, comprising:
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a base substrate having electrodes formed thereon;
a covering layer overlying the base substrate, the covering layer comprising a chamber cover and a body cover having a slot therebetween; and
a unitary spacing layer disposed between the covering layer and the base substrate, the spacing layer having a void that defines a sample receiving chamber between the base substrate and the covering layer;
wherein the slot is in communication with the sample receiving chamber, thereby defining a vent opening in the covering layer that allows air to escape as fluid enters the sample receiving chamber. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A method of manufacturing a plurality of test strips, said method comprising:
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(a) providing a web of base substrate material;
(b) forming a plurality of electrode sets on the web;
(c) providing a reagent layer covering at least one electrode of each electrode set;
then(d) providing a continuous web of spacing material having a series of cavities formed therein and laminating the web of spacing material over the web of base substrate material such that each one of the cavities aligns with a respective one of the electrode sets;
(e) providing a web of covering layer made from two pieces and laminating it over the web of spacing material such that the two pieces are separated by a gap and the gap is positioned over the series of cavities; and
(f) cutting the web into the plurality of test strips. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
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71. A test strip, comprising:
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a test strip body;
a sample receiving chamber disposed in the test strip body;
a fluid receiving opening disposed at an edge of the test strip body and communicating with the sample receiving chamber;
a covering layer at least partially defining the top of the test strip body, the covering layer comprising two pieces having a slot therebetween, the slot forming a vent opening positioned over and in communication with the sample receiving chamber, whereby air can escape through the vent opening as fluid enters the sample receiving chamber; and
the slot comprising a hydrophobic edge, wherein sample fluid can progress into the sample-receiving chamber to the slot, but no farther, whereby the slot comprises a fill line. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85)
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86. A method of testing a fluid sample for the presence or concentration of an analyte, comprising:
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(a) providing a test strip having a sample-receiving opening at an edge thereof, the sample-receiving opening leading into a sample-receiving chamber that extends into the test strip;
(b) providing a covering layer for the test strip formed with a slot that overlies the sample receiving chamber;
(c) placing a fluid sample at the sample receiving opening;
(d) drawing the sample into the sample receiving chamber by capillary action while at the same time displacing air from the sample receiving chamber through the slot;
(e) continuing to draw the sample into the sample receiving chamber until the sample reaches the slot and then halting further progress of the sample beyond the slot, whereby the slot comprises a fill line; and
(f) determining the presence or concentration of the analyte. - View Dependent Claims (87, 88, 89, 90, 91, 92)
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93. A method of testing a fluid sample for the presence or concentration of an analyte, comprising:
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(a) providing a test strip having a sample-receiving opening at an edge thereof, the sample-receiving opening leading into a sample-receiving chamber that extends inwardly on the test strip;
(b) providing a covering layer for the test strip comprising a chamber cover and a body cover with a gap therebetween, the gap overlying a portion of the sample receiving chamber;
(c) placing a fluid sample at the sample receiving opening;
(d) drawing the sample into the sample receiving chamber by capillary action while at the same time displacing air from the sample receiving chamber through the gap, wherein at least a portion of the air displaced exits from the top of the test strip; and
(e) determining the presence or concentration of the analyte. - View Dependent Claims (94, 95, 96, 97)
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98. A test strip, comprising:
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a base substrate having a reagent layer disposed thereon;
a covering layer overlying the base substrate and comprising a chamber cover and a body cover having a slot therebetween, the slot being formed as one of a notch on the underside of the covering layer and an overlap between the covering layer and the chamber cover; and
a sample receiving chamber disposed between the base substrate and the covering layer, the slot being in communication with the sample receiving chamber and defining a vent opening in the covering layer that allows air to escape as fluid enters the sample receiving chamber. - View Dependent Claims (99, 100, 101, 102, 103, 104, 105, 106, 107)
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108. A test strip, comprising:
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a base substrate having a reagent layer disposed thereon;
a covering layer overlying the base substrate and comprising a chamber cover and a body cover having a slot therebetween, the body cover being thicker than the chamber cover; and
a sample receiving chamber disposed between the base substrate and the covering layer, the slot being in communication with the sample receiving chamber and defining a vent opening in the covering layer that allows air to escape as fluid enters the sample receiving chamber. - View Dependent Claims (109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121)
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122. A method of manufacturing test strips, said method comprising:
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(a) providing a first web of material having a series of spaced cavities formed therein, the cavities defining walls and a floor of a sample receiving chamber and the cavities being open on their tops;
(b) covering the first web of material with a second web of material, the second web having a first portion having a first thickness and a second portion having a second thickness greater than the first thickness, wherein the first portion is aligned over and covers the cavities; and
(c) cutting the structure produced in step (b) into the test strips. - View Dependent Claims (123, 124, 125, 126, 127, 128, 129, 130, 131)
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Specification