Tissue integration design for seamless implant fixation

• US 20050015154A1
• Filed: 06/24/2004
• Published: 01/20/2005
• Est. Priority Date: 06/25/2003
• Status: Active Grant

• Current Assignee: Biedermann Technologies GmbH & Co. KG
• Original Assignee: Baylor College of Medicine Office of Technology Administration
• Inventors: Gugala, Zbigniew, Latta, Loren L., Lindsey, Ronald W.
• Granted Patent: US 9,364,330 B2
• Time in Patent Office: Days
• US Class Current: 623/23.460
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61B 17/72 Intramedullary pins, nails or other devices A61B17/744 takes precedence
• CPC Class Codes: A61B 17/7233 with special means of locking the nail to the bone
• CPC Class Codes: A61B 17/7291 for small bones, e.g. in the foot, ankle, hand or wrist
• CPC Class Codes: A61B 17/742 having one or more longitudinal elements oriented along or parallel to the axis of the neck
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/2846 Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006
• CPC Class Codes: A61F 2/30771 applied in original prostheses, e.g. holes or grooves
• CPC Class Codes: A61F 2/30907 Nets or sleeves applied to surface of prostheses or in cement
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/42 for wrists or ankles; for hands, e.g. fingers; for feet, e.g. toes
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30784 Plurality of holes
• CPC Class Codes: A61F 2002/3085 : with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface
• CPC Class Codes: A61F 2002/3092 : having an open-celled or open-pored structure
• CPC Class Codes: A61F 2310/00179 : Ceramics or ceramic-like structures
• CPC Class Codes: A61F 2310/00353 : Bone cement, e.g. polymethylmethacrylate or PMMA
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue
• CPC Class Codes: A61F 2310/00407 : Coating made of titanium or of Ti-based alloys
• CPC Class Codes: A61F 2310/00413 : Coating made of cobalt or of Co-based alloys
• CPC Class Codes: A61F 2310/00592 : Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
• CPC Class Codes: A61F 2310/00796 : Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

Abstract

The present invention relates to orthopaedic implants having a fenestrated hollow shell and a biologic core. These design features provide an improved interface between the implant and the surrounding tissue, aiding fixation, and provide a vehicle for applying new bone healing and enhancing modalities, such as gene therapy, tissue engineering, and growth factors.

Claims

1. A musculo-skeletal implant comprising a fenestrated shell component.

2. The musculo-skeletal implant of claim 1, further comprising a biologic core.

3. The musculo-skeletal implant of claim 2, wherein the fenestrated shell component comprises titanium.

4. The musculo-skeletal implant of claim 2, wherein the fenestrated shell component comprises ceramic material.

5. The musculo-skeletal implant of claim 2, wherein the fenestrated shell component comprises cobalt-chromium.

6. The musculo-skeletal implant of claim 2, wherein the fenestrated shell component comprises diamond shaped fenestrations.

7. The musculo-skeletal implant of claim 2, wherein the fenestrated shell component has a honeycomb pattern, a round pattern, a triangular pattern or any combination thereof.

8. The musculo-skeletal implant of claim 2, wherein the biologic core comprises bone tissue.

9. The musculo-skeletal implant of claim 8, wherein the bone tissue comprises autogenous bone.

10. The musculo-skeletal implant of claim 8, wherein the bone tissue comprises musculo-skeletal autografts, musculo-skeletal allografts, musculo-skeletal xenografts, or any combination thereof.

11. The musculo-skeletal implant of claim 2, wherein the biologic core comprises osteogenic bone graft substitutes, osteoinductive bone graft substitutes, osteoconductive bone graft substitutes or any combination thereof.

12. The musculo-skeletal implant of claim 2, wherein the biological core may be comprised of fibrogenic graft materials, fibroinductive graft materials, fibropromotive graft materials, fibroconductive graft materials, and any combination thereof.

13. The musculo-skeletal implant of claim 2, wherein the biological core may be comprised of chondrogenic graft materials, chondroinductive graft materials, chondropromotive graft materials, chondroconductive graft materials, and any combination thereof.

14. The musculo-skeletal implant of claim 2, wherein the biological core comprises genetic material.

15. The musculo-skeletal implant of claim 14, wherein the genetic material comprises nucleic acids, plasmids, or vectors.

16. The musculo-skeletal implant of claim 2, wherein the biologic core comprises synthetic materials.

17. The musculo-skeletal implant of claim 16, wherein the synthetic materials are selected from the group consisting of ceramics, cement, polymers, and combinations thereof.

18. The musculo-skeletal implant of claim 2, wherein the biologic core comprises a growth factor.

19. The musculo-skeletal implant of claim 18, wherein the growth factor comprises a substance which promotes bone growth.

20. The musculo-skeletal implant of claim 19, wherein the substance comprises bone morphogenetic protein.

21. The musculo-skeletal implant of claim 2, wherein the biologic core comprises a therapeutic agent.

22. The musculo-skeletal implant of claim 21, wherein the therapeutic agent comprises a drug substance.

23. The musculo-skeletal implant of claim 2, wherein the implant is a dental implant.

24. The musculo-skeletal of claim 2, wherein the implant comprises a joint prosthesis.

25. The musculo-skeletal implant of claim 24, wherein the joint prosthesis is selected from the group consisting of hip implants, knee implants, ankle implants, wrist implants, elbow implants, finger implants, foot implants, toe implants, and shoulder implants.

26. The musculo-skeletal implant of claim 24, wherein the joint prosthesis is a vertebral implant.

27. The musculo-skeletal implant of claim 26, wherein the vertebral implant is a spinal disk implant.

28. The musculo-skeletal of claim 2, wherein the implant comprises bone implant hardware.

29. The musculo-skeletal implant of claim 28, wherein the bone implant hardware is selected from the group consisting of bone nails, bone screws, bone rods, and bone plates.

30. The musculo-skeletal implant of claim 28, wherein the bone implant hardware comprises a bone reinforcement implant.

31. The musculo-skeletal implant of claim 2, wherein the implant comprises an extracorporeal prosthesis portion.

32. The musculo-skeletal implant of claim 2, further comprising a coating of material on at least a part of its surface.

33. The musculo-skeletal implant of claim 32, wherein said coating material is hydroxyapatite.

34. The musculo-skeletal implant of claim 2, further comprising a solid, non-fenestrated portion.

35. The musculo-skeletal implant of claim 1, wherein the fenestrated shell component comprises one or more two-dimensional or three-dimensional fenestrated and, at least partially hollow, mechanical structures, said structures having sufficient integrity to maintain its form against its own weight.

36. A musculo-skeletal implant for segmental bone reinforcement, said implant comprising a fenestrated shell component.

37. The musculo-skeletal implant of claim 36, further comprising a biologic core.

38. A method of treating a patient with a musculo-skeletal implant comprising forming an implant having a fenestrated shell component and a biologic core, and implanting the implant into the patient.

39. The method of claim 38, wherein the step of implanting the implant comprises implanting the implant intramedullarly, extramedullarly, juxta-osseously, transosseously, or any combination thereof.

40. The method of claim 38, wherein said musculo-skeletal implant is a joint prosthesis.

41. The method of claim 40, wherein the joint prosthesis is selected from the group consisting of hip, knee, shoulder, ankle, wrist, elbow finger, toe, and foot prostheses.

42. The method of claim 40 wherein, wherein the joint prosthesis is a vertebral implant.

43. The method of claim 42 wherein, wherein the vertebral implant is a spinal disk implant.

44. The method of claim 38 wherein said musculo-skeletal implant forms at least a portion of a hip, knee, shoulder, ankle, wrist, elbow, finger, toe, or foot prosthesis.

45. The method of claim 38, wherein the biologic core comprises material selected from the group consisting of bone material, growth factors, pharmaceutical agents, and a combination thereof.

46. The method of claim 38, wherein the musculo-skeletal implant comprises at least one piece of bone implant hardware.

47. The method of claim 46, wherein the bone implant hardware is selected from the group consisting of intramedullary fixation devices, pins, screws, plates, vertebral discs, nails, rods, and inserts.

48. A method of making a medical implant comprising the step of fabricating a fenestrated shell component from a biocompatible material and loading the fenestrated shell component with a biologically active material.