Pyrimidine derivatives for labeled binding partners

• US 20050020826A1
• Filed: 08/19/2004
• Published: 01/27/2005
• Est. Priority Date: 11/07/1997
• Status: Active Grant

• Current Assignee: Kuei-Ying Lin, Mark E. Matteucci
• Original Assignee: Kuei-Ying Lin, Mark E. Matteucci
• Inventors: Matteucci, Mark E., Lin, Kuei-Ying
• Granted Patent: US 7,511,125 B2
• Time in Patent Office: Days
• US Class Current: 536/27.100
• CPC Class Codes: C07H 19/06 Pyrimidine radicals
• CPC Class Codes: C07H 21/00 Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• CPC Class Codes: C12Q 1/6813 Hybridisation assays
• CPC Class Codes: C12Q 2525/101 incorporating non-naturally occurring nucleotides, e.g. inosine
• CPC Class Codes: C12Q 2563/107 fluorescence
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds having structure (1)
wherein R¹ is —H a protecting group, a linker or a binding partner; and R² and R³⁴ are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.

Claims