Treatment of conditions through modulation of the autonomic nervous system
First Claim
32-1. The method of claim 32, wherein said condition is chosen from:
- sleep apnea, acidemia, hypercapnia, hypoxia ventilation/perfusion, emphysema, chronic obstructive pulmonary disease, primary pulmonary hypertension, secondary pulmonary hypertension, cyctic fibrosis, obesity, obesity hypoventilation syndrome, chronic pulmonary embolism, chronic infection, asthma, inhalational disorders, sarcoid, tuberculosis, pneumoconiosis, coal worker ling, asbestos, left-to-right-shunts, right-to-left shunts, cyanotic lung disease, vascular malformations, atrial septal defects, ventricular septal defects, patent ductus arteriosus, bronchopulmonary dysplasia, granulatomous lung diseases, heart failure, pulmonary edema, usual interstitial pneumonia (UIP), disquamative interstitial pneumonia (DIP), nonspecific interstitial pneumonia (NSIP), lymphocyctic interstitial pneumonia (LIP) acute interstitial pneumonia (AIP), rheumatoid arthritis, wegener'"'"'s granulomatosis, unilateral pneumonectomy, ARDS, histocytosis, bronchiolitis obliterans organizing pneumonia (BOOP), pleural effusion, cancer, sudden death syndromes, congestive heart failure, pulmonary edema, cardiogenic pulmonary edema, non-cardiogenic pulmonary edema, neurogenic edema, emphysema, pulmonary fibrosis, obesity hypoventilation syndrome, HIV, scleroderma, chronic lung diseases, acute lung injury, acute pulmonary embolism, acute respiratory distress syndrome, asphyxiation, drowning, anemia, sickle cell disease, thalassemia, anion gap, non-anion gap, metabolic acidosis, renal tubular acidosis, drug induced acidosis, renal failure, and uremia.
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Abstract
Methods are provided for treating a subject for a condition caused by an abnormality in the subject'"'"'s autonomic nervous system. In accordance with the subject methods, at least a portion of a subject'"'"'s autonomic nervous system is modulated to increase the parasympathetic activity/sympathetic activity ratio in a manner that is effective to treat the subject for the condition. Certain embodiments include modulating at least a portion of a subject'"'"'s autonomic nervous system by inhibiting and/or increasing activity in at least a portion of the subject'"'"'s autonomic nervous system. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
688 Citations
83 Claims
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32-1. The method of claim 32, wherein said condition is chosen from:
- sleep apnea, acidemia, hypercapnia, hypoxia ventilation/perfusion, emphysema, chronic obstructive pulmonary disease, primary pulmonary hypertension, secondary pulmonary hypertension, cyctic fibrosis, obesity, obesity hypoventilation syndrome, chronic pulmonary embolism, chronic infection, asthma, inhalational disorders, sarcoid, tuberculosis, pneumoconiosis, coal worker ling, asbestos, left-to-right-shunts, right-to-left shunts, cyanotic lung disease, vascular malformations, atrial septal defects, ventricular septal defects, patent ductus arteriosus, bronchopulmonary dysplasia, granulatomous lung diseases, heart failure, pulmonary edema, usual interstitial pneumonia (UIP), disquamative interstitial pneumonia (DIP), nonspecific interstitial pneumonia (NSIP), lymphocyctic interstitial pneumonia (LIP) acute interstitial pneumonia (AIP), rheumatoid arthritis, wegener'"'"'s granulomatosis, unilateral pneumonectomy, ARDS, histocytosis, bronchiolitis obliterans organizing pneumonia (BOOP), pleural effusion, cancer, sudden death syndromes, congestive heart failure, pulmonary edema, cardiogenic pulmonary edema, non-cardiogenic pulmonary edema, neurogenic edema, emphysema, pulmonary fibrosis, obesity hypoventilation syndrome, HIV, scleroderma, chronic lung diseases, acute lung injury, acute pulmonary embolism, acute respiratory distress syndrome, asphyxiation, drowning, anemia, sickle cell disease, thalassemia, anion gap, non-anion gap, metabolic acidosis, renal tubular acidosis, drug induced acidosis, renal failure, and uremia.
- 43. A method comprising treating a subject for a condition associated with of least one of hypoxia, hypercapnia, hypercarbia and acidosis, said method comprising modulating at least a portion of said subject'"'"'s autonomic nervous system to increase the parasympathetic activity/sympathetic activity ratio in a manner effective to treat said condition.
Specification