Pullulan film compositions

• US 20050031853A1
• Filed: 09/15/2004
• Published: 02/10/2005
• Est. Priority Date: 07/22/1999
• Status: Active Grant

• Current Assignee: Capsugel Belgium NV (Lonza Group AG)
• Original Assignee: Dominique Cade, Robert Scott, Xiongwei He
• Inventors: Cade, Dominique, Scott, Robert, He, Xiongwei
• Granted Patent: US 7,267,718 B2
• Time in Patent Office: Days
• US Class Current: 428/327
• CPC Class Codes: A61K 9/4816 Wall or shell material
• CPC Class Codes: C08J 2305/00 Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
• CPC Class Codes: C08J 5/18 Manufacture of films or sheets
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: Y10T 428/254 Polymeric or resinous material
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer

Abstract

The invention concerns compositions based on pullulan and a setting system for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. The composition preferably further contains a surfactant. By using aqueous solution of the inventive compositions, the hard pullulan capsules are produced by a conventional dipping moulding process under the same process condition range than conventional gelatine capsules.

Claims

87. A film forming composition comprising:

pullulan;

a surfactant; and

a setting system comprising carrageenan.

88. The film forming composition of claim 87, wherein the surfactant is selected from the group consisting of cationic surfactants, anionic surfactants, non-ionic surfactants, amphoteric surfactants, and mixtures thereof.

89. The film forming composition of claim 87, wherein the surfactant is selected from the group consisting of sodium lauryl sulphate (SLS), dioctyl sodium sulfosuccinate (DDS), benzalkonium chloride, benzethonium chloride, cetrimide (trimethyl-tetradecylammonium bromide), fatty acid sugar esters, glyceryl monooleate, polyoxyethylene sorbitan fatty acid esters, polyvinyl alcohol, dimethylpolysiloxan, sorbitan esters, lecithin, and mixtures thereof.

90. The film forming composition of claim 87, wherein the setting system comprises kappa-carrageenan.

91. The film forming composition of claim 87, wherein the setting system further comprises at least one sequestering agent.

92. The film forming composition of claim 91, wherein the at least one sequestering agent is selected from the group consisting of ethylenediaminetetraacetic acid, acetic acid, boric acid, citric acid, edetic acid, gluconic acid, lactic acid, phosphoric acid, tartaric acid, or salts thereof, methaphosphates, dihydroxyethylglycine, lecithin or beta cyclodextrin.

93. The film forming composition of claim 87, wherein the setting system further comprises cations.

94. A film forming composition comprising:

pullulan;

a surfactant; and

a setting system comprising gellan.

95. The film forming composition of claim 94, wherein the surfactant is selected from the group consisting of cationic surfactants, anionic surfactants, non-ionic surfactants, amphoteric surfactants, and mixtures thereof.

96. The film forming composition of claim 94, wherein the surfactant is selected from the group consisting of sodium lauryl sulphate (SLS), dioctyl sodium sulfosuccinate (DDS), benzalkonium chloride, benzethonium chloride, cetrimide (trimethyl-tetradecylammonium bromide), fatty acid sugar esters, glyceryl monooleate, polyoxyethylene sorbitan fatty acid esters, polyvinyl alcohol, dimethylpolysiloxan, sorbitan esters, lecithin, and mixtures thereof.

97. The film forming composition of claim 94, wherein the setting system further comprises at least one sequestering agent.

98. The film forming composition of claim 97, wherein the at least one sequestering agent is selected from the group consisting of ethylenediaminetetraacetic acid, acetic acid, boric acid, citric acid, edetic acid, gluconic acid, lactic acid, phosphoric acid, tartaric acid, or salts thereof, methaphosphates, dihydroxyethylglycine, lecithin or beta cyclodextrin.

99. The film forming composition of claim 94, wherein the setting system further comprises cations.

100. A capsule comprising:

pullulan;

a surfactant; and

a setting system selected from the group consisting of gellan, carrageenan and mixtures thereof.

101. The film forming composition of claim 100, wherein the surfactant is selected from the group consisting of cationic surfactants, anionic surfactants, non-ionic surfactants, amphoteric surfactants, and mixtures thereof.

102. The film forming composition of claim 100, wherein the surfactant is selected from the group consisting of sodium lauryl sulphate (SLS), dioctyl sodium sulfosuccinate (DDS), benzalkonium chloride, benzethonium chloride, cetrimide (trimethyl-tetradecylammonium bromide), fatty acid sugar esters, glyceryl monooleate, polyoxyethylene sorbitan fatty acid esters, polyvinyl alcohol, dimethylpolysiloxan, sorbitan esters, lecithin, and mixtures thereof.

103. The film forming composition of claim 100, wherein the setting system further comprises at least one sequestering agent.

104. The film forming composition of claim 103, wherein the at least one sequestering agent is selected from the group consisting of ethylenediaminetetraacetic acid, acetic acid, boric acid, citric acid, edetic acid, gluconic acid, lactic acid, phosphoric acid, tartaric acid, or salts thereof, methaphosphates, dihydroxyethylglycine, lecithin or beta cyclodextrin.

105. The film forming composition of claim 100, wherein the setting system further comprises cations.

106. The film forming composition of claim 100, further comprising colouring agents in a range from about 0% to 10% based upon the weight of the composition.