Composition for maintaining organ and cell viability
First Claim
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26-1. A three phase composition comprising the composition of claim 1 admixed with a composition comprising a nanoparticle having an outer lipophilic coating and a hydrophilic inner core comprising a solution or suspension comprising a moiety capable of binding and releasing oxygen.
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Abstract
The present invention is directed to nanoparticle compositions for maintaining organ, tissue and cellular viability when such are separated from normal physiological supports. Compositions containing the nanoparticle compositions and methods of preserving organs such as kidneys, both in vivo and ex vivo, are also disclosed.
62 Citations
32 Claims
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26-1. A three phase composition comprising the composition of claim 1 admixed with a composition comprising a nanoparticle having an outer lipophilic coating and a hydrophilic inner core comprising a solution or suspension comprising a moiety capable of binding and releasing oxygen.
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27-2. The three phase composition of claim 26 wherein the moiety capable of binding and releasing oxygen is a heme protein.
Specification