Method of constructing a biosensor

• US 20050038330A1
• Filed: 08/14/2003
• Published: 02/17/2005
• Est. Priority Date: 08/14/2003
• Status: Active Grant

• Current Assignee: Konamite Limited
• Original Assignee: Isense Corporation
• Inventors: Ward, W. Kenneth, Anderson, Ellen, Jansen, Lawrence B.
• Granted Patent: US 7,529,574 B2
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors

Abstract

A method of creating an analyte sensor. The method starts with the step of providing an electrochemically active surface. Then, at least one nub made of dielectric material and extending transversely outwardly from the electrochemically active surface is created. A curable liquid is applied to the electrochemically active surface and the nub and is then cured. In this process, the nub, which could be one of several nubs, serves to support the liquid before and during the curing.

Claims

1. An indwelling analyte sensor, comprising:

(a) an active sensing region, including;

(i) an electrochemically active surface; and

(ii) a membrane system adhering to said electrochemically active surface;

(b) at least one nub of dielectric material extending outwardly from said electrochemically active surface and serving as a supportive structure to said membrane system.

2. The sensor of claim 1, wherein said at least one nub is in the form of a plate.

3. The sensor of claim 1, wherein said electrochemically active surface is defined as part of a lengthwise body.

4. The sensor of claim 3, wherein said lengthwise body is circular in cross-section.

5. The sensor of claim 4, wherein said electrochemically active surface is circumferential to said circular lengthwise body.

6. The sensor of claim 5, wherein said nubs more specifically comprise annular plates.

7. The sensor of claim 2, wherein said nubs are displaced longitudinally from said electrochemically active surface.

8. The sensor of claim 2, wherein said membrane system includes multiple membranes.

9. The sensor of claim 2, wherein said membrane system includes an enzyme layer.

10. A method of creating an analyte sensor, comprising:

(a) providing an electrochemically active surface;

(b) creating at least one nub made of dielectric material and extending transversely outwardly from said electrochemically active surface;

(c) applying a liquid to said electrochemically active surface and said at least one nub;

(d) curing said liquid; and

(e) whereby said at least one nub serves to support said liquid before and during said curing.

11. The method of claim 10, wherein said at least one nub is in the form of a plate.

12. The method of claim 10, wherein said electrochemically active surface is defined as part of a lengthwise body.

13. The method of claim 10, wherein said lengthwise body is circular in cross-section.

14. The method of claim 13, wherein said electrochemically active surface is circumferential to said circular lengthwise body.

15. The method of claim 14, wherein said nubs more specifically comprise annular plates.

16. The method of claim 10, wherein said nubs are displaced longitudinally from said electrochemically active surface.

17. The method of claim 10, wherein said membrane system includes multiple membranes.

18. The sensor of claim 10, wherein said membrane system includes an enzyme layer.

19. The sensor of claim 10 wherein said at least one nub is created by first providing a wire coated with dielectric material and then removing a portion of said dielectric material formed as a said nub.