Sample adapter

• US 20050070771A1
• Filed: 07/27/2004
• Published: 03/31/2005
• Est. Priority Date: 08/16/2001
• Status: Abandoned Application

• Current Assignee: James R. Braig, Jennifer H. Gable, Peter Rule, Philip C. Hartstein
• Original Assignee: James R. Braig, Jennifer H. Gable, Peter Rule, Philip C. Hartstein
• Inventors: Gable, Jennifer H., Braig, James R., Hartstein, Philip C., Rule, Peter
• Application Number:
  US10/900,062
• Publication Number:
  US 20050070771A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1491 Heated applicators
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

An adapter presents a sample of bodily fluid, such as whole blood, including an analyte to an analyzer window of a non-invasive monitor. The adapter comprises a base material that comprises a first side and a second side. The adapter also comprises a sample accommodating volume extending between an opening in the second side of the base material and an opening in the first side of the base material.

Claims

1-27. -27. (cancelled)

28. A method for calibrating a noninvasive detection unit, said method comprising:

placing a noninvasive sensor portion of said noninvasive detection unit in operative engagement with the skin of a patient;

analyzing a property of an analyte within said patient with said noninvasive detection unit and generating a first monitor output representing said property of said analyte;

withdrawing an amount of bodily fluid from a patient;

placing said noninvasive sensor portion of said noninvasive detection unit in operative engagement with at least some of said withdrawn amount of bodily fluid;

analyzing said property of said analyte in said withdrawn amount of bodily fluid with said noninvasive detection unit and generating a second monitor output representing said property of said analyte, without reference to a prepared standard in which said property of said analyte is predetermined;

comparing said first monitor output and said second monitor output to estimate an error; and

correcting said first monitor output based on said error.

29. The method of claim 28, wherein said bodily fluid is whole blood.

30. The method of claim 29, wherein analyte is glucose and said property is concentration.

31. The method of claim 28, wherein said noninvasive sensor portion comprises an analyzer window of said noninvasive detection unit.

32. The method of claim 28, wherein analyzing said property of said withdrawn amount of bodily fluid in thermal communication with a thermal gradient inducing element of said noninvasive detection unit.

33. The method of claim 32, wherein analyzing said property of said analyte within said patient comprises placing said thermal gradient inducing element in thermal communication with the skin of said patient.

34. A method for calibrating a noninvasive detection unit, said method comprising:

placing a noninvasive sensor portion of said noninvasive detection unit in operative engagement with the skin of a patient;

analyzing a concentration of an analyte within said patient with said noninvasive detection unit and generating a first monitor output representing said concentration of said analyte;

withdrawing an amount of whole blood from a patient;

placing said noninvasive sensor portion of said noninvasive detection unit in operative engagement with at least some of said withdrawn amount of whole blood;

analyzing said property of said analyte in said withdrawn amount of whole blood with said noninvasive detection unit and generating a second monitor output representing a concentration of said analyte in said whole blood;

comparing said first monitor output and said second monitor output to estimate an error; and

correcting said first monitor output based on said error.

35. The method of claim 34, wherein analyte is glucose.

36. The method of claim 34, wherein said noninvasive sensor portion comprises an analyzer window of said noninvasive detection unit.

37. The method of claim 34, wherein analyzing said concentration of said analyte in said withdrawn amount of whole blood comprises placing at least some of said withdrawn amount of whole blood in thermal communication with a thermal gradient inducing element of said noninvasive detection unit.

38. The method of claim 37, wherein analyzing said concentration of said analyte within said patient comprises placing said thermal gradient inducing element in thermal communication with the skin of said patient.

39. A method for calibrating a noninvasive detection unit, said method comprising:

placing a noninvasive sensor portion of said noninvasive detection unit in operative engagement with the skin of a patient;

analyzing a property of an analyte within said patient with said noninvasive detection unit and generating a first monitor output representing said property of said analyte;

withdrawing an amount of bodily fluid from a patient;

placing said noninvasive sensor portion of said noninvasive detection unit in operative engagement with said withdrawn amount of bodily fluid, without mixing said bodily fluid with other fluids;

analyzing said property of said analyte in said withdrawn amount of bodily fluid with said noninvasive detection unit and generating a second monitor output representing said property of said analyte;

comparing said first monitor output and said second monitor output to estimate an error; and

correcting said first monitor output based on said error.

40. The method of claim 39, wherein said bodily fluid is whole blood.

41. The method of claim 40, wherein analyte is glucose and said property is concentration.

42. The method of claim 39, wherein said noninvasive sensor portion comprises an analyzer window of said detection unit.

43. The method of claim 39, wherein analyzing said property of said analyte in said withdrawn amount of bodily fluid comprises placing at least some of said withdrawn amount of bodily fluid in thermal communication with a thermal gradient inducing element of said noninvasive detection unit.

44. The method of claim 43, wherein analyzing said property of said analyte within said patient comprises placing said thermal gradient inducing element in thermal communication with the skin of said patient.