Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
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1. Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases or of other diseases which are accompanied by elevated PLK1 expression levels, characterized in that it reduces or inhibits the activity of polo like kinase 1 (PLK 1) in mammalian cells.
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Abstract
The present invention concerns inhibition of the activity of PLK1, which seems to be connected with cancer growth. Duplex RNAs antisense oligonucleotides and inhibitory peptides have been found to be useful in such inhibition, therefor they are claimed as ingredients fo pharmaceutical compositions for the treatment of proliferative diseases, preferably cancer of various types.
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- 1. Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases or of other diseases which are accompanied by elevated PLK1 expression levels, characterized in that it reduces or inhibits the activity of polo like kinase 1 (PLK 1) in mammalian cells.
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