Implantable heart valve prosthetic devices having intrinsically conductive polymers
First Claim
1. An implantable heart valve sewing prosthesis, the device comprising a ring shaped body having an external surface including an intrinsically conductive polymer having a resistivity of less than about 2000 ohms per square.
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Abstract
A heart valve sewing prosthesis including an intrinsically conductive polymer. The invention includes annuloplasty rings and bands, and sewing rings or cuffs for prosthetic heart valves. Some annuloplasty rings and sewing rings include fabric that is coated with an intrinsically conductive polymer. The coating can be formed over individual filaments or fibers, or on the fabric surface as a surface layer. One intrinsically conductive polymer is polypyrrole. The intrinsically conductive polymer can be doped to facilitate the intrinsic conductivity. Some devices have a polypyrrole surface layer doped with dialkyl-napthalene sulfonate. The intrinsically conductive polymer can be deposited on a fabric using in-situ polymerization of monomeric or oligomeric species, together with a dopant. Animal studies using implanted annuloplasty rings having an intrinsically conductive polymer coating have demonstrated a substantial reduction in pannus formation and inflammatory response.
222 Citations
41 Claims
- 1. An implantable heart valve sewing prosthesis, the device comprising a ring shaped body having an external surface including an intrinsically conductive polymer having a resistivity of less than about 2000 ohms per square.
- 7. A blood contacting implantable biomedical device comprising an external surface having an intrinsically conductive polymer layer, wherein the device is selected from the group consisting of heart valve annuloplasty rings, heart valve annuloplasty bands, mechanical prosthetic heart valves, and bioprosthetic heart valves.
- 20. An annuloplasty prosthesis for implanting in a heart valve annulus in a patient, the annuloplasty prosthesis comprising a ring shaped body comprising an intrinsically conductive polymer.
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27. A prosthetic heart valve for implanting in a patient, the heart valve comprising:
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an annular housing having a flow channel therethrough for the passage of blood, an inside surface forming the flow channel for blood, and an outside surface for facing heart tissue;
a valve flow control member moveably secured to the housing and having an open position and a closed position; and
a ring shaped body disposed about the annular housing outside surface, wherein the ring shaped body has external surface comprising an intrinsically conductive polymer. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A stented bioprosthetic heart valve for implanting in a patient, the heart valve comprising:
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an annular housing having a flow channel therethrough for the passage of blood, an inside surface forming the flow channel for blood, and an outside surface for facing heart tissue;
at least one moveable tissue leaflet secured to the housing and having an open position and a closed position; and
a ring shaped body disposed about the annular housing outside surface, wherein the ring shaped body has external surface comprising an intrinsically conductive polymer. - View Dependent Claims (36, 37, 38, 39, 40, 41)
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Specification